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ADAM10 ADAM metallopeptidase domain 10 [ Gallus gallus (chicken) ]

Gene ID: 374113, updated on 3-Apr-2024

Summary

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Symbol
ADAM10provided by CGNC
Full Name
ADAM metallopeptidase domain 10provided by CGNC
Primary source
CGNC:3093
See related
Ensembl:ENSGALG00010025336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
17
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (6952500..6996045)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (6827498..6870881)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene SAFB like transcription modulator Neighboring gene uncharacterized LOC124417125 Neighboring gene family with sequence similarity 63 member B Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC124417123 Neighboring gene lipase C, hepatic type Neighboring gene aquaporin 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ADAM 10: an active metalloprotease expressed during avian epithelial morphogenesis. Hall RJ, et al. Dev Biol, 2003 Apr 1. PMID 12654298
  2. ADAM10 mediates N-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina. Paudel S, et al. J Cell Biochem, 2013 Apr. PMID 23129104
  3. Suppression of ADAM 10-induced Delta-1 shedding inhibits cell proliferation during the chondro-inhibitory action of TGF-beta3. Jin EJ, et al. Mol Cells, 2007 Aug 31. PMID 17846509
  4. Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development. Markus A, et al. Cell Mol Biol Lett, 2011 Sep. PMID 21786032, Free PMC Article
  5. Differential regional expression of multiple ADAMs during feather bud formation. Lin J, et al. Dev Dyn, 2011 Sep. PMID 21780243

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAM10 kockdown suppresses the ganglion cell differentiation.
    Title: ADAM10 mediates N-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina.
  2. ADAM9, ADAM10, and ADAM17 are expressed in the epidermis of the feather bud.
    Title: Differential regional expression of multiple ADAMs during feather bud formation.
  3. in cultured chick leg bud mesenchyme cells, TGF-beta 3 downregulates ADAM 10 & inhibits cell proliferation & subsequent precartilage condensation by inhibiting the ectodomain shedding of delta-1, & that this results in the activation of Notch signaling.
    Title: Suppression of ADAM 10-induced Delta-1 shedding inhibits cell proliferation during the chondro-inhibitory action of TGF-beta3.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 10
Names
a disintegrin and metalloproteinase domain 10
NP_989592.3
XP_046754831.1
XP_046754832.1
XP_046780415.1
XP_046780416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204261.3 → NP_989592.3  disintegrin and metalloproteinase domain-containing protein 10 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000245
    UniProtKB/TrEMBL
    F1P1J6, Q5F3N4, Q8QFX0
    Related
    ENSGALP00010038194.1, ENSGALT00010061867.1
    Conserved Domains (3) summary
    smart00050
    Location:467 → 546
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:221 → 460
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:46 → 156
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    6952500..6996045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046898875.1 → XP_046754831.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

  2. XM_046898876.1 → XP_046754832.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    6827498..6870881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924459.1 → XP_046780415.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

  2. XM_046924460.1 → XP_046780416.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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