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BTK Bruton tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 374075, updated on 3-Apr-2024

Summary

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Official Symbol
BTKprovided by CGNC
Official Full Name
Bruton tyrosine kinaseprovided by CGNC
Primary source
CGNC:3685
See related
Ensembl:ENSGALG00010015975
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (1984163..1995856)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (2020642..2032333)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene glycine receptor alpha 4 Neighboring gene galactosidase alpha Neighboring gene ribosomal protein L36a Neighboring gene translocase of inner mitochondrial membrane 8A Neighboring gene magnesium transporter NIPA2-like Neighboring gene TATA-box binding protein associated factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression profiling of chicken DT40 lymphoma cells indicates clonal selection of knockout and gene reconstituted cells. Nawaz HM, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18930021
  2. Cloning and functional characterization of chicken stem cell antigen 2. Mao W, et al. Dev Comp Immunol, 2010 Mar. PMID 19945479
  3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microarray analysis of SCA-2 induced bursal cells showed BTK to be among the under-expressed genes and this was validated with qRT-PCR.
    Title: Cloning and functional characterization of chicken stem cell antigen 2.
  2. Expression profiling of Btk defective DT40 lymphoma cells
    Title: Expression profiling of chicken DT40 lymphoma cells indicates clonal selection of knockout and gene reconstituted cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase BTK
Names
Bruton agammaglobulinemia tyrosine kinase
NP_989564.2
XP_015133649.1
XP_015133650.1
XP_046771349.1
XP_046771350.1
XP_046771351.1
XP_046771352.1
XP_046771353.1
XP_046771354.1
XP_046771355.1
XP_046771356.1
XP_046771357.1
XP_046771358.1
XP_046771359.1
XP_046771360.1
XP_046771361.1
XP_046771362.1
XP_046795789.1
XP_046795790.1
XP_046795791.1
XP_046795792.1
XP_046795793.1
XP_046795794.1
XP_046795795.1
XP_046795796.1
XP_046795797.1
XP_046795798.1
XP_046795799.1
XP_046795800.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204233.3 → NP_989564.2  tyrosine-protein kinase BTK

    See identical proteins and their annotated locations for NP_989564.2

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000071
    UniProtKB/Swiss-Prot
    Q8JH64
    UniProtKB/TrEMBL
    Q5ZLF2
    Conserved Domains (6) summary
    cd05113
    Location:395 → 650
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:271 → 377
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:214 → 268
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:6 → 165
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam00169
    Location:4 → 132
    PH; PH domain
    pfam07714
    Location:400 → 646
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1984163..1995856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046939839.1 → XP_046795795.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  2. XM_046939842.1 → XP_046795798.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  3. XM_046939843.1 → XP_046795799.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  4. XM_046939834.1 → XP_046795790.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  5. XM_046939838.1 → XP_046795794.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  6. XM_046939840.1 → XP_046795796.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  7. XM_046939841.1 → XP_046795797.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  8. XM_046939844.1 → XP_046795800.1  tyrosine-protein kinase BTK isoform X3

  9. XM_015278163.4 → XP_015133649.1  tyrosine-protein kinase BTK isoform X1

    UniProtKB/Swiss-Prot
    Q8JH64
    Conserved Domains (6) summary
    cd05113
    Location:437 → 692
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:313 → 419
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:256 → 310
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:48 → 207
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam00169
    Location:46 → 174
    PH; PH domain
    pfam07714
    Location:442 → 688
    Pkinase_Tyr; Protein tyrosine kinase

  10. XM_015278164.4 → XP_015133650.1  tyrosine-protein kinase BTK isoform X2

    UniProtKB/Swiss-Prot
    Q8JH64
    Conserved Domains (6) summary
    cd05113
    Location:436 → 691
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:312 → 418
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:255 → 309
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:48 → 206
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam00169
    Location:46 → 173
    PH; PH domain
    pfam07714
    Location:441 → 687
    Pkinase_Tyr; Protein tyrosine kinase

  11. XM_046939836.1 → XP_046795792.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  12. XM_046939837.1 → XP_046795793.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2
    Related
    ENSGALP00010022279.1, ENSGALT00010038503.1

  13. XM_046939835.1 → XP_046795791.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2
    Related
    ENSGALP00010022278.1, ENSGALT00010038502.1

  14. XM_046939833.1 → XP_046795789.1  tyrosine-protein kinase BTK isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2020642..2032333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915402.1 → XP_046771358.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  2. XM_046915404.1 → XP_046771360.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  3. XM_046915405.1 → XP_046771361.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  4. XM_046915396.1 → XP_046771352.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  5. XM_046915400.1 → XP_046771356.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  6. XM_046915401.1 → XP_046771357.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  7. XM_046915403.1 → XP_046771359.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  8. XM_046915406.1 → XP_046771362.1  tyrosine-protein kinase BTK isoform X3

  9. XM_046915393.1 → XP_046771349.1  tyrosine-protein kinase BTK isoform X1

  10. XM_046915394.1 → XP_046771350.1  tyrosine-protein kinase BTK isoform X2

  11. XM_046915398.1 → XP_046771354.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  12. XM_046915399.1 → XP_046771355.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  13. XM_046915397.1 → XP_046771353.1  tyrosine-protein kinase BTK isoform X4

    UniProtKB/TrEMBL
    Q5ZLF2

  14. XM_046915395.1 → XP_046771351.1  tyrosine-protein kinase BTK isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JH64.1 GenPept UniProtKB/Swiss-Prot:Q8JH64

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