ITGB1 integrin subunit beta 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: ITGB1provided by CGNC
Full Name: integrin subunit beta 1provided by CGNC
Primary source: CGNC:49025
See related: Ensembl:ENSGALG00010005632
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (13975109..14016571)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (14001390..14042797)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The integrin-Wnt7a-Decorin pathway promotes proliferation and differentiation of neuroepithelial cells.
Title: Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
Normal fibroblasts promote myodifferentiation of myoblasts from sex-linked dwarf chicken via up-regulation of beta1 integrin
Title: Normal fibroblasts promote myodifferentiation of myoblasts from sex-linked dwarf chicken via up-regulation of β1 integrin.
Beta1 integrin can regulate cell shape and tissue morphogenesis indirectly, by regulation of downstream signalling cascades.
Title: Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesis.
Data show that increased levels of liprin-alpha1 affected the localization of inactive, low-affinity integrins, while increasing the average size of beta1 integrin-positive focal adhesions.
Title: Liprin-alpha1 affects the distribution of low-affinity beta1 integrins and stabilizes their permanence at the cell surface.
Results suggest that SCO-spondin has a role in the development of the PC through its interaction with integrin beta1.
Title: Polarized expression of integrin beta1 in diencephalic roof plate during chick development, a possible receptor for SCO-spondin.
Data suggest that cooperation between alpha(4)beta(1)/alpha(5)beta(1) and RGD integrins is important for epicardial mesothelial cell adhesion and subepicardial matrix formation.
Title: Communication between integrin receptors facilitates epicardial cell adhesion and matrix organization.
We provide a hypothesis whereby a combination of activated surface integrin levels and the degree to which those receptors are clustered determines NCC motility on fibronectin.
Title: Neural crest motility on fibronectin is regulated by integrin activation.
MMP-2 mediates the inhibitory signals of p38MAPK during mesenchymal cell condensation via interactions with fibronectin through integrin beta1
Title: MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK-integrin beta1 interaction.
Retinal ganglion cell beta 1-integrins are the key adhesion molecules stabilizing developing dendritic arbors.
Title: Dendritic arbors of developing retinal ganglion cells are stabilized by beta 1-integrins.
Results suggest that the integrin alpha4beta1 is important for survival of developing retinal neurons, including retinal ganglion cells.
Title: Integrin alpha4beta1 function is required for cell survival in developing retina.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables C-X3-C chemokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables collagen binding involved in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
enables fibronectin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables laminin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: integrin beta-1

Names: CSAT antigen; JG22 antigen; RGD-receptor; integrin beta1D; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039254.3 → NP_001034343.2 integrin beta-1 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000036

UniProtKB/TrEMBL

A0A8V0XST5

Related

ENSGALP00010008013.1, ENSGALT00010013496.1

Conserved Domains (3) summary

pfam00362
Location:38 → 469

Integrin_beta; Integrin, beta chain

pfam07965
Location:645 → 732

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:762 → 800

Integrin_b_cyt; Integrin beta cytoplasmic domain