MYOD1 myogenic differentiation 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: MYOD1provided by CGNC
Full Name: myogenic differentiation 1provided by CGNC
Primary source: CGNC:4667
See related: Ensembl:ENSGALG00010024369
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (11805090..11808553)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (11773754..11777222)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vgl-2 acts downstream of MyoD activation and is associated with the differentiation step in embryonic skeletal myogenesis
Title: Vestigial-like 2 acts downstream of MyoD activation and is associated with skeletal muscle differentiation in chick myogenesis.
Study demonstrates that MyoD expressing cells serve as a Noggin delivery system to regulate the morphogenesis of the lens and optic cup.
Title: Noggin producing, MyoD-positive cells are crucial for eye development.
MyoD-positive epiblast cells are stasbly committed to the skeletal muscle cell lineage.
Title: Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage.
NeuroM and MyoD are present in separate subpopulations of cells in the pregastrulating epiblast; epiblast cells with NeuroM are more dependent on exogenous factors to differentiate than those with MyoD
Title: NeuroM and MyoD are expressed in separate subpopulations of cells in the pregastrulating epiblast.
MyoD expression is regulated by Hoxa-11 and Hoxa-13 in limb muscle precursors
Title: Hoxa-11 and Hoxa-13 are involved in repression of MyoD during limb muscle development.
These results demonstrate that MyoD-positive epiblast cells recruit pluripotent cells to the skeletal muscle lineage through a mechanism thatinvolves blocking the BMP signaling pathway [MyoD].
Title: Epiblast cells that express MyoD recruit pluripotent cells to the skeletal muscle lineage.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: myoblast determination protein 1 homolog

Names: MYOD1 homolog; myogenic factor 1; myogenic factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204214.3 → NP_989545.3 myoblast determination protein 1 homolog

Status: VALIDATED

Source sequence(s)

JAENSK010000214

UniProtKB/Swiss-Prot

P16075, Q90916

UniProtKB/TrEMBL

F1NHM3

Related

ENSGALP00010036294.1, ENSGALT00010059435.1

Conserved Domains (2) summary

smart00520
Location:7 → 106

BASIC; Basic domain in HLH proteins of MYOD family

cd18936
Location:97 → 157

bHLH_TS_MYOD1_Myf3; basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and similar proteins