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CCND2 cyclin D2 [ Gallus gallus (chicken) ]

Gene ID: 374047, updated on 3-Apr-2024

Summary

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Symbol
CCND2provided by CGNC
Full Name
cyclin D2provided by CGNC
Primary source
CGNC:12983
See related
Ensembl:ENSGALG00010024285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (73569617..73614521, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (73898809..73943742, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 23 Neighboring gene uncharacterized LOC112530139 Neighboring gene TP53 induced glycolysis regulatory phosphatase Neighboring gene uncharacterized LOC121109358 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and gene expression of avian cyclin D2. Li H, et al. Gene, 1995 Dec 29. PMID 8566807
  2. Specific regulation of cyclins D1 and D2 by FGF and Shh signaling coordinates cell cycle progression, patterning, and differentiation during early steps of spinal cord development. Lobjois V, et al. Dev Biol, 2004 Sep 15. PMID 15328007
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGF signaling maintains cyclin D2 in the immature caudal neural epithelium, while Shh activates cyclin D1 in the neural groove.
    Title: Specific regulation of cyclins D1 and D2 by FGF and Shh signaling coordinates cell cycle progression, patterning, and differentiation during early steps of spinal cord development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
G1/S-specific cyclin-D2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397876.1 → NP_001384805.1  G1/S-specific cyclin-D2 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/Swiss-Prot
    P49706
    Conserved Domains (2) summary
    cd20574
    Location:1 → 150
    CYCLIN_CCND2_rpt1; first cyclin box found in G1/S-specific cyclin-D2 (CCND2)
    cd20577
    Location:155 → 258
    CYCLIN_CCND2_rpt2; second cyclin box found in G1/S-specific cyclin-D2 (CCND2)

  2. NM_001397877.1 → NP_001384806.1  G1/S-specific cyclin-D2 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012

  3. NM_001397878.1 → NP_001384807.1  G1/S-specific cyclin-D2 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    Related
    ENSGALP00010036146.1, ENSGALT00010059221.1
    Conserved Domains (2) summary
    cd20574
    Location:1 → 150
    CYCLIN_CCND2_rpt1; first cyclin box found in G1/S-specific cyclin-D2 (CCND2)
    cl40454
    Location:155 → 240
    CYCLIN_SF; Cyclin box fold superfamily

  4. NM_204213.2 → NP_989544.1  G1/S-specific cyclin-D2 isoform a

    See identical proteins and their annotated locations for NP_989544.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/Swiss-Prot
    P49706
    UniProtKB/TrEMBL
    A0A8V0ZRS2
    Related
    ENSGALP00010036169.1, ENSGALT00010059249.1
    Conserved Domains (2) summary
    cd20574
    Location:1 → 150
    CYCLIN_CCND2_rpt1; first cyclin box found in G1/S-specific cyclin-D2 (CCND2)
    cd20577
    Location:155 → 258
    CYCLIN_CCND2_rpt2; second cyclin box found in G1/S-specific cyclin-D2 (CCND2)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    73569617..73614521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046940683.1 → XP_046796639.1  G1/S-specific cyclin-D2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZWY2
    Related
    ENSGALP00010036152.1, ENSGALT00010059229.1

RNA

  1. XR_006939155.1 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    73898809..73943742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906330.1 → XP_046762286.1  G1/S-specific cyclin-D2 isoform X2

RNA

  1. XR_006932627.1 RNA Sequence

  2. XR_006932626.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49706.1 GenPept UniProtKB/Swiss-Prot:P49706

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.