NOTCH2 notch 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: NOTCH2provided by CGNC
Full Name: notch 2provided by CGNC
Primary source: CGNC:49013
See related: Ensembl:ENSGALG00010013323
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	8	NC_052539.1 (4165167..4244193)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	8	NC_052580.1 (4176846..4255913)

Chromosome 8 - NC_052539.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Notch2, Hey1 and Hey2 initiate a signaling cascade that delimits the non-chamber atrioventricular canal (AVC) and inner curvature (IC) regions of the developing heart.
Title: Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors.
Delta1-mediated Notch signaling among endodermal cells functions as a binary switch for determination of glandular and luminal fates
Title: Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Notch binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to tumor cell	IEA Inferred from Electronic Annotation more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of developmental process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neurogenic locus notch homolog protein 2

Names: Notch homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252033.2 → NP_001238962.2 neurogenic locus notch homolog protein 2 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000237

UniProtKB/TrEMBL

A0A8V0YDK7, A0A8V0YRT4

Related

ENSGALP00010018891.1, ENSGALT00010032101.1

Conserved Domains (7) summary

PTZ00322
Location:1958 → 2060

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

smart00004
Location:1472 → 1510

NL; Domain found in Notch and Lin-12

PHA03095
Location:1769 → 2006

PHA03095; ankyrin-like protein; Provisional

cd00054
Location:185 → 222

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00045
Location:1919 → 1950

ANK; ANK repeat [structural motif]

pfam03326
Location:2043 → 2389

Herpes_TAF50; Herpesvirus transcription activation factor (transactivator)

cl02419
Location:1435 → 1472

Notch; LNR domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

4165167..4244193

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040704449.2 → XP_040560383.1 neurogenic locus notch homolog protein 2 isoform X1

Conserved Domains (1) summary

cd00054
Location:185 → 222

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...