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PSEN1 presenilin 1 [ Gallus gallus (chicken) ]

Gene ID: 373977, updated on 3-Apr-2024

Summary

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Official Symbol
PSEN1provided by CGNC
Official Full Name
presenilin 1provided by CGNC
Primary source
CGNC:7083
See related
Ensembl:ENSGALG00010020984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PS-1; presenilin-1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (25889584..25910988, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (25856249..25877655, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene NUMB, endocytic adaptor protein Neighboring gene translation initiation factor IF-2-like Neighboring gene papilin, proteoglycan like sulfated glycoprotein Neighboring gene uncharacterized LOC121111006 Neighboring gene translation initiation factor IF-2-like Neighboring gene RNA binding motif protein 25 Neighboring gene zinc finger FYVE-type containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1. Rubio ME, et al. Mol Cell Neurosci, 2005 Sep. PMID 16046145
  2. Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules. Mirinics ZK, et al. Blood Cells Mol Dis, 2002 Jan-Feb. PMID 11987239
  3. Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick. Bar-Shira E, et al. Dev Comp Immunol, 2006. PMID 16430960
  4. Expressed sequence tag analysis of Eimeria-stimulated intestinal intraepithelial lymphocytes in chickens. Min W, et al. Mol Biotechnol, 2005 Jun. PMID 15920284
  5. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors use expression of presenilin 1 to demonstrate that granulocytes complete functional maturation in gut
    Title: Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick.
  2. changes in the molecular composition of the N-cadherin complex (represented by the uncoupling of p120-catenin and association with PS1) may correspond to distinct functional states of the complex involved in synaptic maturation
    Title: Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-1
NP_989494.2
XP_015142400.1
XP_040556470.1
XP_040556472.1
XP_046773584.1
XP_046773585.1
XP_046773586.1
XP_046773587.1
XP_046797300.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204163.3 → NP_989494.2  presenilin-1

    See identical proteins and their annotated locations for NP_989494.2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000214
    UniProtKB/Swiss-Prot
    Q4JIM4, Q90X08
    UniProtKB/TrEMBL
    A0A8V0ZGP0
    Related
    ENSGALP00010029949.1, ENSGALT00010050723.1
    Conserved Domains (1) summary
    pfam01080
    Location:77 → 458
    Presenilin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    25889584..25910988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040700536.2 → XP_040556470.1  presenilin-1 isoform X2

    UniProtKB/Swiss-Prot
    Q4JIM4, Q90X08
    UniProtKB/TrEMBL
    A0A8V0ZGP0
    Conserved Domains (1) summary
    pfam01080
    Location:77 → 458
    Presenilin

  2. XM_040700538.2 → XP_040556472.1  presenilin-1 isoform X2

    UniProtKB/Swiss-Prot
    Q4JIM4, Q90X08
    UniProtKB/TrEMBL
    A0A8V0ZGP0
    Conserved Domains (1) summary
    pfam01080
    Location:77 → 458
    Presenilin

  3. XM_046941344.1 → XP_046797300.1  presenilin-1 isoform X2

    UniProtKB/Swiss-Prot
    Q4JIM4, Q90X08

  4. XM_015286914.4 → XP_015142400.1  presenilin-1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UE42, A0A8V0ZMP0
    Related
    ENSGALP00010029948.1, ENSGALT00010050722.1
    Conserved Domains (1) summary
    pfam01080
    Location:77 → 458
    Presenilin

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    25856249..25877655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917629.1 → XP_046773585.1  presenilin-1 isoform X2

    UniProtKB/Swiss-Prot
    Q4JIM4, Q90X08

  2. XM_046917631.1 → XP_046773587.1  presenilin-1 isoform X2

    UniProtKB/Swiss-Prot
    Q4JIM4, Q90X08

  3. XM_046917630.1 → XP_046773586.1  presenilin-1 isoform X2

    UniProtKB/Swiss-Prot
    Q4JIM4, Q90X08

  4. XM_046917628.1 → XP_046773584.1  presenilin-1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UE42
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4JIM4.1 GenPept UniProtKB/Swiss-Prot:Q4JIM4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.