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ROCK1 Rho-associated, coiled-coil containing protein kinase 1 [ Gallus gallus (chicken) ]

Gene ID: 373970, updated on 3-Apr-2024

Summary

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Official Symbol
ROCK1provided by CGNC
Official Full Name
Rho-associated, coiled-coil containing protein kinase 1provided by CGNC
Primary source
CGNC:11078
See related
Ensembl:ENSGALG00010005048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
34
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (101788760..101866636, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (101853087..101930949, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene THO complex 1 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene uncharacterized LOC107051997 Neighboring gene GREB1 like retinoic acid receptor coactivator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Downregulation of ROCK-I and ROCK-II gene expression in the cadmium-induced ventral body wall defect chick model. Doi T, et al. Pediatr Surg Int, 2008 Dec. PMID 18956198
  2. Rho kinase inhibitor Y27632 affects initial heart myofibrillogenesis in cultured chick blastoderm. Sakata H, et al. Dev Dyn, 2007 Feb. PMID 17195179
  3. RHOA-ROCK signalling is necessary for lateralization and differentiation of the developing sinoatrial node. Vicente-Steijn R, et al. Cardiovasc Res, 2017 Aug 1. PMID 28899000
  4. Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling. Kosla J, et al. Cell Commun Signal, 2013 Jul 30. PMID 23899007, Free PMC Article
  5. Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Wei L, et al. Development, 2001 Aug. PMID 11532918

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RHOA-ROCK signalling is involved in establishing the right-sided sinoatrial node as the definitive pacemaker of the heart and restricts typical pacemaker gene expression to the right side of the sinus venosus myocardium.
    Title: RHOA-ROCK signalling is necessary for lateralization and differentiation of the developing sinoatrial node.
  2. Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.
    Title: Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling.
  3. the downregulation of ROCK-I and ROCK-II gene expressions during this narrow window of embryogenesis may cause ventral body wall defect by disrupting Wnt non-canonical pathway.
    Title: Downregulation of ROCK-I and ROCK-II gene expression in the cadmium-induced ventral body wall defect chick model.
  4. the expression of ROCK1 is up-regulated at the onset of endocardial epithelial-mesenchymal transition and signaling mediated by TGFbeta3/ALK2 together with BMP is involved in the expression of ROCK1
    Title: ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation.
  5. ROCK1 plays a role in the formation of initial heart myofibrillogenesis by means of actin-myosin assembly, and focal adhesion/costamere and cell-cell adhesion.
    Title: Rho kinase inhibitor Y27632 affects initial heart myofibrillogenesis in cultured chick blastoderm.
  6. Rho kinase phosphorylates CRMP-2, and inactivates the ability of CRMP-2 to promote microtubule assembly and Numb-mediated endocytosis, during growth cone collapse
    Title: Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in embryonic morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho-associated protein kinase 1
NP_001186377.2
XP_015133417.2
XP_046766133.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199448.2 → NP_001186377.2  rho-associated protein kinase 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000043
    UniProtKB/TrEMBL
    A0A8V0XIZ2, A0A8V0XRE1
    Related
    ENSGALP00010006661.1, ENSGALT00010011898.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    101788760..101866636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015277931.4 → XP_015133417.2  rho-associated protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XLH6, A0A8V0XRE1
    Related
    ENSGALP00010006664.1, ENSGALT00010011901.1
    Conserved Domains (5) summary
    smart00109
    Location:1233 → 1287
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd11639
    Location:491 → 556
    HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
    cd01242
    Location:1123 → 1229
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05622
    Location:2 → 406
    STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
    TIGR02168
    Location:474 → 1104
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    101853087..101930949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910177.1 → XP_046766133.1  rho-associated protein kinase 1 isoform X1

RNA

  1. XR_006933374.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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