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PPARG peroxisome proliferator-activated receptor gamma [ Gallus gallus (chicken) ]

Gene ID: 373928, updated on 3-Apr-2024

Summary

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Official Symbol
PPARGprovided by CGNC
Official Full Name
peroxisome proliferator-activated receptor gammaprovided by CGNC
Primary source
CGNC:3698
See related
Ensembl:ENSGALG00010027917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PPARgamma; PPARgamma2
Orthologs
human mouse all
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Genomic context

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See PPARG in Genome Data Viewer
Location:
chromosome: 12
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (5019526..5074079)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (5043781..5098334)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene synapsin II Neighboring gene TIMP metallopeptidase inhibitor 4 Neighboring gene uncharacterized LOC124417163 Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand Neighboring gene makorin ring finger protein 2 Neighboring gene Raf-1 proto-oncogene, serine/threonine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ligands and Regulatory Modes of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Avians. Navidshad B, et al. Crit Rev Eukaryot Gene Expr, 2015. PMID 26559088
  2. Identification and characterization of transcript variants of chicken peroxisome proliferator-activated receptor gamma. Duan K, et al. Poult Sci, 2015 Oct. PMID 26286997
  3. Epigenetic DNA methylation in the promoters of peroxisome proliferator-activated receptor γ in chicken lines divergently selected for fatness. Sun YN, et al. J Anim Sci, 2014 Jan. PMID 24305869
  4. [Characterization of chicken PPARγ expression and its impact on adipocyte proliferation and differentiation]. Wang L, et al. Yi Chuan, 2012 Apr. PMID 22522163
  5. Functional analysis of the chicken PPARγ gene 5'-flanking region and C/EBPα-mediated gene regulation. Ding N, et al. Comp Biochem Physiol B Biochem Mol Biol, 2011 Apr. PMID 21238598

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of dried natto diet on the transcript levels of the peroxisome proliferator-activated receptor-gamma, coactivator-1alpha and -1beta, and nuclear receptor corepressor 1 genes in laying hens.
    Title: Effects of dried natto diet on the transcript levels of the peroxisome proliferator-activated receptor-γ, coactivator-1α and -1β, and nuclear receptor corepressor 1 genes in laying hens.
  2. The most important metabolic effect of PPARgamma in chicken is its task in adipogenesis. Reviewing the ligands of chicken PPARgamma gene can be useful to a better understanding of PPARgamma regulatory functions. [Review]
    Title: Ligands and Regulatory Modes of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Avians.
  3. Open reading frame analysis showed that five cPPARgamma transcript variants (cPPARgamma1 to 5) could encode two cPPARgamma protein isoforms (cPPARgamma1 and cPPARgamma2), which differ only in their N-terminal region. cPPARgamma1 was highly expressed in various chicken tissues.
    Title: Identification and characterization of transcript variants of chicken peroxisome proliferator-activated receptor gamma.
  4. PPARgamma gene promoter methylation in both chicken lines decreased with age, and PPARgamma promoter methylation levels were significantly higher in lean than fat broilers at 2, 3, and 7 wk of age.
    Title: Epigenetic DNA methylation in the promoters of peroxisome proliferator-activated receptor γ in chicken lines divergently selected for fatness.
  5. PPARgamma involved in lipid metabolism in Beijing-You chickens and it's expression in thigh was highest at hatching and decreased significantly at 4 and 8 weeks.
    Title: Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens.
  6. PPARgamma gene may be related to the broiler abdominal fat deposition, and be probably a key regulator of chicken adipocyte proliferation and differentiation.
    Title: [Characterization of chicken PPARγ expression and its impact on adipocyte proliferation and differentiation].
  7. Peroxisome proliferator-activated receptor gamma (PPARgamma) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism.
    Title: Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism.
  8. the HMG1A and PPARG genes were candidate genes for abdominal fat deposition in chickens
    Title: HMG1A and PPARG are differently expressed in the liver of fat and lean broilers.
  9. A-FABP knockdown might lead to decreased lipid accumulation and upregulated expression of PPAR-gamma in chicken adipocytes.
    Title: Chicken adipocyte fatty acid-binding protein knockdown affects expression of peroxisome proliferator-activated receptor γ gene during oleate-induced adipocyte differentiation.
  10. the chicken C/EBPalpha could directly bind to and regulate the PPARgamma gene promoter.
    Title: Functional analysis of the chicken PPARγ gene 5'-flanking region and C/EBPα-mediated gene regulation.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peroxisome proliferator-activated receptor gamma
Names
peroxisome proliferative activated receptor, gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001460.2 → NP_001001460.1  peroxisome proliferator-activated receptor gamma

    See identical proteins and their annotated locations for NP_001001460.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000252
    UniProtKB/TrEMBL
    A0A0S1NES2, Q9I878
    Related
    ENSGALP00010041415.1, ENSGALT00010067672.1
    Conserved Domains (3) summary
    cd06932
    Location:207 → 474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 78
    PPARgamma_N; PPAR gamma N-terminal region

  2. NM_001397666.1 → NP_001384595.1  peroxisome proliferator-activated receptor gamma

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000252
    UniProtKB/TrEMBL
    Q9I878
    Conserved Domains (3) summary
    cd06932
    Location:207 → 474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 78
    PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5019526..5074079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040646063.2 → XP_040501997.1  peroxisome proliferator-activated receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A0S1NES2, Q9I878
    Conserved Domains (3) summary
    cd06932
    Location:207 → 474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108 → 191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 78
    PPARgamma_N; PPAR gamma N-terminal region

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5043781..5098334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046925952.1 → XP_046781908.1  peroxisome proliferator-activated receptor gamma isoform X1

    UniProtKB/TrEMBL
    Q9I878
Nucleotide Protein Strain
Heading Accession and Version

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