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NR1H4 nuclear receptor subfamily 1 group H member 4 [ Gallus gallus (chicken) ]

Gene ID: 373902, updated on 5-Mar-2024

Summary

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Symbol
NR1H4provided by CGNC
Full Name
nuclear receptor subfamily 1 group H member 4provided by CGNC
Primary source
CGNC:8812
See related
Ensembl:ENSGALG00010011566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (47369939..47421635)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (47666998..47718695)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene SCY1 like pseudokinase 2 Neighboring gene solute carrier family 17 member 8 Neighboring gene growth arrest specific 2 like 3 Neighboring gene anoctamin 4 Neighboring gene solute carrier family 5 member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. Handschin C, et al. J Biol Chem, 2002 Aug 16. PMID 12045201
  2. FOR, a novel orphan nuclear receptor related to farnesoid X receptor. Seo YW, et al. J Biol Chem, 2002 May 17. PMID 11867625

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables bile acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bile acid signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bile acid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396910.1 → NP_001383839.1  bile acid receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    Conserved Domains (2) summary
    cd06936
    Location:252 → 472
    NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
    cd06962
    Location:125 → 212
    NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers

  2. NM_001396911.1 → NP_001383840.1  bile acid receptor isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    Conserved Domains (2) summary
    cd06936
    Location:218 → 438
    NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
    cd06962
    Location:91 → 178
    NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers

  3. NM_001396912.1 → NP_001383841.1  bile acid receptor isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    Conserved Domains (2) summary
    cd06936
    Location:214 → 434
    NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
    cd06962
    Location:91 → 174
    NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers

  4. NM_204113.3 → NP_989444.1  bile acid receptor isoform 2

    See identical proteins and their annotated locations for NP_989444.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    F6QU14, Q8JHU2
    Conserved Domains (2) summary
    cd06936
    Location:248 → 468
    NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
    cd06962
    Location:125 → 208
    NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    47369939..47421635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046937991.1 → XP_046793947.1  bile acid receptor isoform X1

  2. XM_046938081.1 → XP_046794037.1  bile acid receptor isoform X2

    UniProtKB/TrEMBL
    F6QU14, Q8JHU2

  3. XM_046938195.1 → XP_046794151.1  bile acid receptor isoform X5

  4. XM_046938098.1 → XP_046794054.1  bile acid receptor isoform X2

    UniProtKB/TrEMBL
    F6QU14, Q8JHU2
    Related
    ENSGALP00010015863.1, ENSGALT00010027681.1

  5. XM_046938017.1 → XP_046793973.1  bile acid receptor isoform X1

  6. XM_046938171.1 → XP_046794127.1  bile acid receptor isoform X5

  7. XM_046938124.1 → XP_046794080.1  bile acid receptor isoform X3

  8. XM_046938147.1 → XP_046794103.1  bile acid receptor isoform X4

    UniProtKB/TrEMBL
    A0A8V0YA53
    Related
    ENSGALP00010015860.1, ENSGALT00010027677.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    47666998..47718695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906250.1 → XP_046762206.1  bile acid receptor isoform X1

  2. XM_046906252.1 → XP_046762208.1  bile acid receptor isoform X2

    UniProtKB/TrEMBL
    F6QU14, Q8JHU2

  3. XM_046906257.1 → XP_046762213.1  bile acid receptor isoform X5

  4. XM_046906253.1 → XP_046762209.1  bile acid receptor isoform X2

    UniProtKB/TrEMBL
    F6QU14, Q8JHU2

  5. XM_046906251.1 → XP_046762207.1  bile acid receptor isoform X1

  6. XM_046906256.1 → XP_046762212.1  bile acid receptor isoform X5

  7. XM_046906254.1 → XP_046762210.1  bile acid receptor isoform X3

  8. XM_046906255.1 → XP_046762211.1  bile acid receptor isoform X4

    UniProtKB/TrEMBL
    A0A8V0YA53
Nucleotide Protein Strain
Heading Accession and Version

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