FZD4 frizzled class receptor 4 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: FZD4provided by CGNC
Official Full Name: frizzled class receptor 4provided by CGNC
Primary source: CGNC:12957
See related: Ensembl:ENSGALG00010007763
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: FZ4; FZ-4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (188625664..188631337)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (188650771..188656434)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye
Title: Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Wnt receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in retina vasculature morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: frizzled-4

Names: cFz-4; frizzled family receptor 4; frizzled homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204099.2 → NP_989430.1 frizzled-4 precursor

See identical proteins and their annotated locations for NP_989430.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000027

UniProtKB/Swiss-Prot

Q9IA05, Q9PTW2

UniProtKB/TrEMBL

A0A8V0XTU8

Related

ENSGALP00010010101.1, ENSGALT00010018449.1

Conserved Domains (2) summary

cd07448
Location:30 → 155

CRD_FZ4; Cysteine-rich Wnt-binding domain of the frizzled 4 (Fz4) receptor

cd15038
Location:197 → 497

7tmF_FZD4; class F frizzled subfamily 4, member of 7-transmembrane G protein-coupled receptors