Prosalpha3 Proteasome alpha3 subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prosalpha3provided by FlyBase
Official Full Name: Proteasome alpha3 subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0261394
Locus tag: Dmel_CG9327
See related: AllianceGenome:FB:FBgn0261394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha-3; Alpha-3; alpha3; alpha3_dm; CG9327; Dmel\CG9327; PROS-29; Pros-alpha3; Pros20S-alpha3; pros29; Pros29; prosalpha3; PSB3_DROME
Summary: Predicted to enable threonine-type endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Located in cytoplasm and nucleus. Part of proteasome core complex. Is expressed in several structures, including adult heart; embryonic/larval salivary gland; gastrula embryo; ovary; and testis. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (20994900..20996118)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (16882405..16883623)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables peptidase activity	IKR Inferred from Key Residues more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

Names: 20s proteasome; CG9327-PA; Prosalpha3-PA; alpha-subunit of 20S proteasome; alpha3; proteasome 20S alpha3 subunit; proteasome 29kD subunit; proteasome subunit alpha-type 4

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