pak1 p21 protein (Cdc42/Rac)-activated kinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pak1provided by ZNC
Official Full Name: p21 protein (Cdc42/Rac)-activated kinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030826-29
See related: Ensembl:ENSDARG00000103959 AllianceGenome:ZFIN:ZDB-GENE-030826-29
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb761; wu:fj97h10
Summary: Enables identical protein binding activity and protein kinase activity. Acts upstream of with a positive effect on Wnt signaling pathway involved in dorsal/ventral axis specification and canonical Wnt signaling pathway. Acts upstream of or within animal organ development and convergent extension. Predicted to be active in cytoplasm. Is expressed in several structures, including axial mesoderm; cardiovascular system; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (3169911..3284188)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (3268382..3319326, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these data suggest an essential role for Pak1 as an Erk activator, and Gata6 as an Erk target, during neural crest development.
Title: A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.
Two functional endothelial cell-specific miRNAs, miR-126a and miR-126b, synergistically regulate zebrafish vascular integrity, and pak1 is a critical target of miR-126a/b in vascular development.
Title: Two functional microRNA-126s repress a novel target gene p21-activated kinase 1 to regulate vascular integrity in zebrafish.
LC8 facilitates nuclear import of Pak1 and this function is indispensable during vertebrate development
Title: Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bulbus arteriosus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pro-T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 1

Names: p21/Cdc42/Rac1-activated kinase 1

NP_958485.1

EC 2.7.11.1

XP_021323273.1

EC 2.7.11.1

XP_021323274.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201328.1 → NP_958485.1 serine/threonine-protein kinase PAK 1

See identical proteins and their annotated locations for NP_958485.1

Status: PROVISIONAL

Source sequence(s)

BC044138

UniProtKB/TrEMBL

Q803Z0

Related

ENSDARP00000132462.2, ENSDART00000164724.2

Conserved Domains (3) summary

smart00220
Location:302 → 553

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00786
Location:73 → 128

PBD; P21-Rho-binding domain

cl21453
Location:281 → 576

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

3169911..3284188

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467598.1 → XP_021323273.1 serine/threonine-protein kinase PAK 1 isoform X1

UniProtKB/TrEMBL

A0A8M9P9X9

Conserved Domains (2) summary

pfam00786
Location:73 → 130

PBD; P21-Rho-binding domain

cl21453
Location:283 → 586

PKc_like; Protein Kinases, catalytic domain
XM_021467599.1 → XP_021323274.1 serine/threonine-protein kinase PAK 1 isoform X2

UniProtKB/TrEMBL

A0A8M9PFA6

Related

ENSDARP00000132912.2, ENSDART00000166580.2

Conserved Domains (2) summary

pfam00786
Location:73 → 130

PBD; P21-Rho-binding domain

cl21453
Location:283 → 578

PKc_like; Protein Kinases, catalytic domain