gys2 glycogen synthase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gys2provided by ZNC
Official Full Name: glycogen synthase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030826-31
See related: Ensembl:ENSDARG00000004904 AllianceGenome:ZFIN:ZDB-GENE-030826-31
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb765; zgc:112057
Summary: Predicted to enable glycogen (starch) synthase activity. Predicted to be involved in glycogen biosynthetic process and response to glucose. Predicted to be located in cortical actin cytoskeleton; cytosol; and ectoplasm. Predicted to be active in cytoplasm. Is expressed in liver and male organism. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (16800022..16824324, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (16811046..16835348, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glycogen (starch) synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycogen (starch) synthase activity	IEA Inferred from Electronic Annotation more info
enables glycogen (starch) synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucose	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in cortical actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glycogen [starch] synthase, liver

NP_001018199.1

EC 2.4.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001018679.1 → NP_001018199.1 glycogen [starch] synthase, liver

See identical proteins and their annotated locations for NP_001018199.1

Status: PROVISIONAL

Source sequence(s)

BC095660

UniProtKB/TrEMBL

Q502K7, Q5RGX8

Related

ENSDARP00000002983.7, ENSDART00000014007.8

Conserved Domains (2) summary

cd03793
Location:27 → 616

GT1_Glycogen_synthase_GSY2_like; Glycogen synthase, which is most closely related to the GT1 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the ...

pfam05693
Location:32 → 655

Glycogen_syn; Glycogen synthase