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sm smooth [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37254, updated on 10-May-2024

Summary

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Official Symbol
smprovided by FlyBase
Official Full Name
smoothprovided by FlyBase
Primary source
FLYBASE:FBgn0003435
Locus tag
Dmel_CG9218
See related
AllianceGenome:FB:FBgn0003435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH10856; CG9218; Dmel\CG9218; l(2)05338; Sm; smo
Summary
Predicted to enable mRNA binding activity. Involved in adult feeding behavior; axon guidance; and determination of adult lifespan. Located in nucleoplasm. Is expressed in adult head; central nervous system; embryonic/larval nervous system; and spermatocyte. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to several human genes including HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
56D15-56E1; 2-90 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19517864..19631508, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15405369..15519013, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 56c Neighboring gene Ionotropic receptor 56d Neighboring gene transfer RNA:Glutamic acid-TTC 1-3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44473 Neighboring gene long non-coding RNA:CR44474 Neighboring gene Tubulin tyrosine ligase-like 6A Neighboring gene long non-coding RNA:CR44503 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function. Draper I, et al. Fly (Austin), 2009 Oct-Dec. PMID 19755840, Free PMC Article
  2. Genetic and molecular analysis of smooth, a quantitative trait locus affecting bristle number in Drosophila melanogaster. zur Lage P, et al. Genetics, 1997 Jun. PMID 9178010, Free PMC Article
  3. Smooth, a hnRNP encoding gene, controls axonal navigation in Drosophila. Layalle S, et al. Genes Cells, 2005 Feb. PMID 15676023
  4. Short cryptic exons mediate recursive splicing in Drosophila. Joseph B, et al. Nat Struct Mol Biol, 2018 May. PMID 29632374, Free PMC Article
  5. Evaluation of the role of functional constraints on the integrity of an ultraconserved region in the genus Drosophila. Díaz-Castillo C, et al. PLoS Genet, 2012 Feb. PMID 22319453, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of the smooth/CG9218 locus leads to age-dependent muscle degeneration, and motor dysfunction.
    Title: The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adult feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
smooth
Names
CG9218-PA
CG9218-PAA
CG9218-PAB
CG9218-PAC
CG9218-PB
CG9218-PE
CG9218-PG
CG9218-PH
CG9218-PI
CG9218-PJ
CG9218-PK
CG9218-PL
CG9218-PM
CG9218-PO
CG9218-PP
CG9218-PT
CG9218-PU
CG9218-PV
CG9218-PW
CG9218-PY
CG9218-PZ
sm-PA
sm-PAA
sm-PAB
sm-PAC
sm-PB
sm-PE
sm-PG
sm-PH
sm-PI
sm-PJ
sm-PK
sm-PL
sm-PM
sm-PO
sm-PP
sm-PT
sm-PU
sm-PV
sm-PW
sm-PY
sm-PZ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19517864..19631508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259505.2 → NP_001246434.1  smooth, isoform AA [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246434.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K8A2
    Conserved Domains (3) summary
    cd12424
    Location:275 → 346
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:393 → 475
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:75 → 160
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  2. NM_001259497.2 → NP_001246426.1  smooth, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246426.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K852
    Conserved Domains (3) summary
    cd12424
    Location:264 → 335
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:382 → 464
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  3. NM_001259500.2 → NP_001246429.1  smooth, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246429.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K8A1
    Conserved Domains (3) summary
    cd12424
    Location:282 → 353
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:400 → 482
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:75 → 160
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  4. NM_001274164.1 → NP_001261093.1  smooth, isoform AB [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261093.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF04
    Conserved Domains (3) summary
    cd12424
    Location:276 → 347
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:394 → 476
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  5. NM_001259498.2 → NP_001246427.1  smooth, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246427.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7B0
    Conserved Domains (3) summary
    cd12424
    Location:263 → 334
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:381 → 461
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  6. NM_001259495.2 → NP_001246424.1  smooth, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246424.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5AEJ9
    Conserved Domains (2) summary
    cd12424
    Location:231 → 302
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:349 → 431
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  7. NM_166368.5 → NP_725913.2  smooth, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725913.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHD5
    Conserved Domains (3) summary
    cd12424
    Location:201 → 272
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:319 → 401
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cl17169
    Location:51 → 119
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. NM_057383.7 → NP_476731.1  smooth, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMZ7
    Related
    FBpp0085681
    Conserved Domains (3) summary
    cd12424
    Location:242 → 313
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:360 → 442
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  9. NM_001259494.2 → NP_001246423.1  smooth, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246423.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7H8
    Conserved Domains (3) summary
    cd12424
    Location:302 → 373
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:420 → 502
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  10. NM_001259496.2 → NP_001246425.1  smooth, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246425.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7W3
    Conserved Domains (3) summary
    cd12424
    Location:259 → 330
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:377 → 459
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  11. NM_001259499.2 → NP_001246428.1  smooth, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246428.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7I2
    Conserved Domains (3) summary
    cd12424
    Location:319 → 390
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:437 → 519
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  12. NM_001032268.3 → NP_001027439.2  smooth, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027439.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NND8
    Conserved Domains (3) summary
    cd12424
    Location:247 → 318
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:365 → 447
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  13. NM_001259501.2 → NP_001246430.1  smooth, isoform V [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246430.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7W7
    Conserved Domains (3) summary
    cd12424
    Location:307 → 378
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:425 → 507
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  14. NM_001032269.3 → NP_001027440.1  smooth, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027440.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMZ7
    Conserved Domains (3) summary
    cd12424
    Location:242 → 313
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:360 → 442
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  15. NM_001259504.2 → NP_001246433.1  smooth, isoform Z [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246433.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7I6
    Conserved Domains (3) summary
    cd12424
    Location:258 → 329
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:376 → 458
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12694
    Location:80 → 165
    RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  16. NM_001259502.2 → NP_001246431.1  smooth, isoform W [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246431.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E914
    Conserved Domains (2) summary
    cd12424
    Location:27 → 98
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:145 → 227
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  17. NM_001043096.2 → NP_001036561.1  smooth, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E914
    Conserved Domains (2) summary
    cd12424
    Location:27 → 98
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:145 → 227
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  18. NM_001259503.2 → NP_001246432.1  smooth, isoform Y [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246432.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E914
    Conserved Domains (2) summary
    cd12424
    Location:27 → 98
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:145 → 227
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  19. NM_001274165.1 → NP_001261094.1  smooth, isoform AC [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261094.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEV0
    Conserved Domains (2) summary
    cd12424
    Location:68 → 139
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:186 → 268
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  20. NM_166369.5 → NP_725914.1  smooth, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBN3
    Related
    FBpp0085684
    Conserved Domains (2) summary
    cd12424
    Location:171 → 242
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:289 → 371
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

  21. NM_166370.5 → NP_725915.2  smooth, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725915.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBN4, Q8IHH3
    Conserved Domains (2) summary
    cd12424
    Location:187 → 258
    RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
    cd12427
    Location:305 → 387
    RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7B0 A0A0B4K7B0
A0A0B4K7H8 A0A0B4K7H8
A0A0B4K7I2 A0A0B4K7I2
A0A0B4K7I6 A0A0B4K7I6
A0A0B4K7W3 A0A0B4K7W3
A0A0B4K7W7 A0A0B4K7W7
A0A0B4K852 A0A0B4K852
A0A0B4K8A1 A0A0B4K8A1
A0A0B4K8A2 A0A0B4K8A2
A0A0B4KEV0 A0A0B4KEV0
A0A0B4KF04 A0A0B4KF04
A0A0C4DHD5 A0A0C4DHD5
A1ZBN3 A1ZBN3
D5AEJ9 D5AEJ9
Q0E914 Q0E914
Q6NND8 Q6NND8
Q7JMZ7 Q7JMZ7
Q86P89 Q86P89
Q8IHH3 Q8IHH3
Q8SXP5 Q8SXP5

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