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C3L secreted complement-binding protein [ Vaccinia virus ]

Gene ID: 3707640, updated on 18-Aug-2023

Summary

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Gene symbol
C3L
Gene description
secreted complement-binding protein
Locus tag
VACWR025
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Vaccinia virus (strain: WR (Western Reserve))
Lineage
Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus
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Genomic context

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Sequence:
NC_006998.1 (18677..19468, complement)

NC_006998.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene kelch-like protein Neighboring gene Hypothetical protein Neighboring gene temporal expression: early/late

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006998.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Vaccinia virus complement control protein modulates adaptive immune responses during infection. Girgis NM, et al. J Virol, 2011 Mar. PMID 21191012, Free PMC Article
  2. Glycosylated and nonglycosylated complement control protein of the lister strain of vaccinia virus. Meseda CA, et al. Clin Vaccine Immunol, 2014 Sep. PMID 25030055, Free PMC Article
  3. Genomic sequence of a clonal isolate of the vaccinia virus Lister strain employed for smallpox vaccination in France and its comparison to other orthopoxviruses. Garcel A, et al. J Gen Virol, 2007 Jul. PMID 17554021

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
secreted complement-binding protein
YP_232907.1
  • secreted complement-binding protein; binds host complement components C3b and C4b to modulate the host inflammatory response; blocks both classical and alternative pathways of complement activity; similar to Vaccinia virus Copenhagen C3L; the poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006998.1 Reference assembly

    Range
    18677..19468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_232907.1 secreted complement binding C3b/C4b [Vaccinia virus]

    See identical proteins and their annotated locations for YP_232907.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P10998, P68638, P68639, Q76ZY4
    UniProtKB/TrEMBL
    A0A2I2MBW6, A4GD81, A9J1F2, M9WKE1, Q1M2I1, Q49PX4, Q77TN7, S5G1Q4
    Conserved Domains (1) summary
    PHA02927
    Location:1 → 263
    PHA02927; secreted complement-binding protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAO89304.1

Gene LinkOut

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