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eIF3b eukaryotic translation initiation factor 3 subunit b [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36981, updated on 4-Apr-2024

Summary

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Official Symbol
eIF3bprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 3 subunit bprovided by FlyBase
Primary source
FLYBASE:FBgn0034237
Locus tag
Dmel_CG4878
See related
AllianceGenome:FB:FBgn0034237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg4878; CG4878; Dmel\CG4878; eIF3; eIF3 S9; eIF3-s9; eIF3-S9; eIF3B; EIF3B; SN2-6
Summary
Predicted to enable mRNA binding activity. Predicted to contribute to translation initiation factor activity. Involved in ovarian follicle cell development. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central nervous system; embryonic/larval midgut; and extended germ band embryo. Orthologous to human EIF3B (eukaryotic translation initiation factor 3 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See eIF3b in Genome Data Viewer
Location:
54C3-54C3; 2-83 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17536213..17539142)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13423718..13426647)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Anaphase Promoting Complex subunit 10 Neighboring gene patronin Neighboring gene uncharacterized protein Neighboring gene Coiled-coil and C2 domain containing 2A Neighboring gene uncharacterized protein Neighboring gene cyclophilin-33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. Farny NG, et al. RNA, 2009 Oct. PMID 19661161, Free PMC Article
  2. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Goodman LD, et al. Acta Neuropathol Commun, 2019 Apr 25. PMID 31023341, Free PMC Article
  3. The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation. Andersen DS, et al. J Biol Chem, 2007 May 18. PMID 17392269
  4. The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm. Ramat A, et al. Cell Res, 2020 May. PMID 32132673, Free PMC Article
  5. DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation. Linsalata AE, et al. EMBO Rep, 2019 Sep. PMID 31347257, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit b
Names
CG4878-PA
CG4878-PB
eIF3-S9
eIF3b-PA
eIF3b-PB
suppressor of NA9 2-6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17536213..17539142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137384.3 → NP_611228.1  eukaryotic translation initiation factor 3 subunit b, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611228.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0PUW0, Q0E940, Q8MR84
    UniProtKB/TrEMBL
    E2QCG7
    Related
    FBpp0086097
    Conserved Domains (4) summary
    COG5354
    Location:194 → 690
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    cd12278
    Location:56 → 137
    RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
    sd00039
    Location:216 → 248
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:216 → 352
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_166239.4 → NP_725691.1  eukaryotic translation initiation factor 3 subunit b, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725691.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0PUW0, Q0E940, Q8MR84
    UniProtKB/TrEMBL
    E2QCG7
    Related
    FBpp0086098
    Conserved Domains (4) summary
    COG5354
    Location:194 → 690
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    cd12278
    Location:56 → 137
    RRM_eIF3B; RNA recognition motif in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
    sd00039
    Location:216 → 248
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:216 → 352
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QCG7 E2QCG7
Q0E940.1 Q0E940

Gene LinkOut

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