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Prosalpha5 Proteasome alpha5 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36951, updated on 5-May-2024

Summary

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Official Symbol
Prosalpha5provided by FlyBase
Official Full Name
Proteasome alpha5 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0016697
Locus tag
Dmel_CG10938
See related
AllianceGenome:FB:FBgn0016697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
154644_at; alpha-5; Alpha-5; alpha5; alpha5_dm; CG10938; Dmel\CG10938; PRCZ; prosalpha5; prosMA5; ProsMA5; PSA5_DROME; PSMA5
Summary
Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of with a positive effect on determination of adult lifespan. Part of proteasome core complex. Is expressed in several structures, including adult head; adult heart; anterior endoderm anlage; gastrula embryo; and germline cell. Orthologous to human PSMA5 (proteasome 20S subunit alpha 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
54B7-54B7; 2-82 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17412767..17413769)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13300272..13301274)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cathelicidin-like antimicrobial protein Neighboring gene Vajk4 Neighboring gene connector enhancer of ksr Neighboring gene lethal (2) k01209 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteomic mapping of Drosophila transgenic elav.L-GAL4/+ brain as a tool to illuminate neuropathology mechanisms. Velentzas AD, et al. Sci Rep, 2020 Mar 25. PMID 32214222, Free PMC Article
  2. Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3. Johnson SL, et al. Neurobiol Dis, 2019 Dec. PMID 31310802, Free PMC Article
  3. The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle. Langerak S, et al. Biol Open, 2018 Apr 26. PMID 29615416, Free PMC Article
  4. Molecular cloning of the Drosophila melanogaster gene alpha5_dm encoding a 20S proteasome alpha-type subunit. Zaiss D, et al. Gene, 1997 Nov 12. PMID 9409776
  5. Quantitative Proteomics Reveals Extensive Changes in the Ubiquitinome after Perturbation of the Proteasome by Targeted dsRNA-Mediated Subunit Knockdown in Drosophila. Sap KA, et al. J Proteome Res, 2017 Aug 4. PMID 28665616

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
acts_upstream_of_positive_effect determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome alpha5 subunit
Names
20s proteasome
CG10938-PA
CG10938-PB
Prosalpha5-PA
Prosalpha5-PB
alpha-subunit of 20S proteasome
alpha5
proteasome alpha subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17412767..17413769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166221.4 → NP_725669.1  proteasome alpha5 subunit, isoform A [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E942, Q95083, Q9V809
    Related
    FBpp0086066
    Conserved Domains (2) summary
    PRK03996
    Location:8 → 243
    PRK03996; proteasome subunit alpha; Provisional
    cd03753
    Location:8 → 222
    proteasome_alpha_type_5; proteasome_alpha_type_5. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

  2. NM_057854.4 → NP_477202.2  proteasome alpha5 subunit, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E942, Q95083, Q9V809
    Related
    FBpp0086067
    Conserved Domains (2) summary
    PRK03996
    Location:8 → 243
    PRK03996; proteasome subunit alpha; Provisional
    cd03753
    Location:8 → 222
    proteasome_alpha_type_5; proteasome_alpha_type_5. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95083.2 Q95083

Gene LinkOut

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