tgfb2 transforming growth factor, beta 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tgfb2provided by ZNC
Official Full Name: transforming growth factor, beta 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030723-3
See related: Ensembl:ENSDARG00000027087 AllianceGenome:ZFIN:ZDB-GENE-030723-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Acts upstream of or within roof of mouth development and sclerotome development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including mandibular arch skeleton; mesoderm; otic placode; pericardial region; and periocular mesenchyme. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (2745006..2807527, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (2507340..2569861, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study found that Bptf and TGF-beta/Smad2 mediate nucleosome remodeling to regulate wnt8a expression and hence neural posteriorization.
Title: The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression.
Functional investigation of a subset of these genes, fgf10a, tgfb2, pax9, and smad5 revealed their necessity in zebrafish palatogenesis.
Title: Examination of a palatogenic gene program in zebrafish.
These data suggest Pez plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.
Title: The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development.

Submit: New GeneRIF Correction

General gene information

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Markers

G46087 (e-PCR)
- UniSTS:106889

G47201 (e-PCR)
- UniSTS:107987

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sclerotome development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transforming growth factor beta-2 proprotein

Names: tgf beta 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194385.1 → NP_919366.1 transforming growth factor beta-2 proprotein precursor

See identical proteins and their annotated locations for NP_919366.1

Status: PROVISIONAL

Source sequence(s)

AY338730

UniProtKB/TrEMBL

Q7SZV4

Related

ENSDARP00000123937.1, ENSDART00000148927.2

Conserved Domains (2) summary

pfam00688
Location:21 → 228

TGFb_propeptide; TGF-beta propeptide

cd19385
Location:314 → 410

TGF_beta_TGFB2; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins