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Paip1 Poly(A) binding protein interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36913, updated on 4-Apr-2024

Summary

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Official Symbol
Paip1provided by FlyBase
Official Full Name
Poly(A) binding protein interacting protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0034181
Locus tag
Dmel_CG8963
See related
AllianceGenome:FB:FBgn0034181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8963; Dmel\CG8963
Summary
Predicted to enable translation activator activity. Predicted to be involved in regulation of translational initiation. Is expressed in adult head and organism. Orthologous to human PAIP1 (poly(A) binding protein interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
53E4-53E4; 2-81 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17016226..17019522, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12903731..12907027, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Eps15 homology domain containing protein-binding protein 1 Neighboring gene antisense RNA:CR44390 Neighboring gene Death-associated APAF1-related killer Neighboring gene Rho guanine nucleotide exchange factor 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila. Funakoshi M, et al. Biochem Biophys Res Commun, 2011 Feb 25. PMID 21281604
  2. Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Akdemir F, et al. Development, 2006 Apr. PMID 16540507
  3. B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster. Vrailas-Mortimer AD, et al. MicroPubl Biol, 2021 Jan 18. PMID 33474526, Free PMC Article
  4. Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster. Yamamoto A, et al. Genet Res (Camb), 2009 Dec. PMID 19968911
  5. Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Yamamoto A, et al. Proc Natl Acad Sci U S A, 2008 Aug 26. PMID 18713854, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Poly(A) binding protein interacting protein 1
Names
CG8963-PA
CG8963-PB
CG8963-PC
CG8963-PE
Paip1-PA
Paip1-PB
Paip1-PC
Paip1-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17016226..17019522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206145.3 → NP_995867.1  Poly(A) binding protein interacting protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K581
    Conserved Domains (1) summary
    smart00543
    Location:270 → 472
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)

  2. NM_137336.4 → NP_611180.1  Poly(A) binding protein interacting protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611180.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K581
    Related
    FBpp0086167
    Conserved Domains (1) summary
    smart00543
    Location:270 → 472
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)

  3. NM_001169700.2 → NP_001163171.1  Poly(A) binding protein interacting protein 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163171.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K581
    Conserved Domains (1) summary
    smart00543
    Location:270 → 472
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)

  4. NM_001259451.2 → NP_001246380.2  Poly(A) binding protein interacting protein 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246380.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K891
    Conserved Domains (1) summary
    smart00543
    Location:231 → 433
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K891 A0A0B4K891
Q7K581 Q7K581

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