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srsf3a serine and arginine rich splicing factor 3a [ Danio rerio (zebrafish) ]

Gene ID: 368925, updated on 27-Mar-2024

Summary

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Official Symbol
srsf3aprovided by ZNC
Official Full Name
serine and arginine rich splicing factor 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-631
See related
Ensembl:ENSDARG00000025397 Ensembl:ENSDARG00000100815 AllianceGenome:ZFIN:ZDB-GENE-030616-631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sfrs3; sfrs3a; zgc:86626; si:zc263a23.9
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nuclear speck. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 6
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (41080002..41091244, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (41082467..41093708, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene RAB44, member RAS oncogene family Neighboring gene FKBP prolyl isomerase 5 Neighboring gene solute carrier family 6 member 22, tandem duplicate 1 Neighboring gene solute carrier family 6 member 22, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets. Gangras P, et al. PLoS Genet, 2020 Jun. PMID 32502192, Free PMC Article
  2. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
  3. prpf4 is essential for cell survival and posterior lateral line primordium migration in zebrafish. Wang Y, et al. J Genet Genomics, 2018 Aug 20. PMID 30174136
  4. Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Liu C, et al. Sci Rep, 2015 Jan 29. PMID 25630924, Free PMC Article
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 3; serine/arginine-rich splicing factor 3a
Names
splicing factor, arginine/serine-rich 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002053.2 → NP_001002053.1  serine/arginine-rich splicing factor 3a

    See identical proteins and their annotated locations for NP_001002053.1

    Status: VALIDATED

    Source sequence(s)
    BC071322, EH518653
    UniProtKB/TrEMBL
    Q6IQT2, Q801U3
    Related
    ENSDARP00000035207.6, ENSDART00000028217.8
    Conserved Domains (2) summary
    COG0724
    Location:13 → 97
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:10 → 90
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001328122.2 → NP_001315051.1  serine/arginine-rich splicing factor 3a

    Status: VALIDATED

    Source sequence(s)
    AL732567, EH518653, EH527237, EH564513, EH606039
    UniProtKB/TrEMBL
    Q6IQT2, Q801U3
    Related
    ENSDARP00000128223.1, ENSDART00000153818.3
    Conserved Domains (2) summary
    COG0724
    Location:13 → 97
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:10 → 90
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    41080002..41091244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302539.3 → XP_009300814.1  serine/arginine-rich splicing factor 3 isoform X1

    See identical proteins and their annotated locations for XP_009300814.1

    UniProtKB/TrEMBL
    Q6IQT2, Q801U3
    Conserved Domains (2) summary
    COG0724
    Location:13 → 97
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:10 → 90
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_661961.3 RNA Sequence

  2. XR_661960.3 RNA Sequence

    Related
    ENSDART00000154587.3
Nucleotide Protein Strain
Heading Accession and Version

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