ITGAM integrin subunit alpha M [Homo sapiens (human)] - Gene

Summary

Official Symbol: ITGAMprovided by HGNC
Official Full Name: integrin subunit alpha Mprovided by HGNC
Primary source: HGNC:HGNC:6149
See related: Ensembl:ENSG00000169896 MIM:120980; AllianceGenome:HGNC:6149
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
Summary: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Expression: Biased expression in bone marrow (RPKM 72.3), appendix (RPKM 14.6) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p11.2

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (31259975..31332877)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (31647380..31720298)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (31271296..31344198)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis.
Title: ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis.
Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.
Title: Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.
CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization.
Title: CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization.
Immune Inhibitory Molecule PD-1 Homolog (VISTA) Colocalizes with CD11b Myeloid Cells in Melanoma and Is Associated with Poor Outcomes.
Title: Immune Inhibitory Molecule PD-1 Homolog (VISTA) Colocalizes with CD11b Myeloid Cells in Melanoma and Is Associated with Poor Outcomes.
NFIL3 aggravates human coronary artery endothelial cell injury by promoting ITGAM transcription in Kawasaki disease.
Title: NFIL3 aggravates human coronary artery endothelial cell injury by promoting ITGAM transcription in Kawasaki disease.
Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.
Title: Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.
Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b.
Title: Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b.
Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity.
Title: Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity.
ITGAM rs1143679 Variant in Systemic Lupus Erythematosus Is Associated with Increased Serum Calcification Propensity.
Title: ITGAM rs1143679 Variant in Systemic Lupus Erythematosus Is Associated with Increased Serum Calcification Propensity.
The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation.
Title: The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation.

Submit: New GeneRIF Correction See all GeneRIFs (268)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. EBI GWAS Catalog EBI GWAS CatalogPubMed
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1	PubMed
Nef	nef	HIV-1 Nef interacts with complement receptor 3 (CR3) in a manner that allows CR3 redistribution toward bacterial-induced pseudopods in macrophages	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, alpha M (ITGAM, CR3A) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed
matrix	gag	HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH79892 (e-PCR)
- UniSTS:89004

D16S753 (e-PCR), detects polymorphism
- UniSTS:26598

GDB:180920 (e-PCR)
- UniSTS:155125

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables amyloid-beta binding	IC Inferred by Curator more info
contributes_to cargo receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables cargo receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables complement component C3b binding	ISS Inferred from Sequence or Structural Similarity more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	NAS Non-traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement receptor mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in complement-mediated synapse pruning	ISS Inferred from Sequence or Structural Similarity more info
involved_in ectodermal cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in forebrain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in microglial cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of dopamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microglial cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil degranulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of prostaglandin-E synthase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of superoxide anion generation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of superoxide anion generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in response to curcumin	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in vertebrate eye-specific patterning	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	HDA more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphaM-beta2 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in specific granule membrane	TAS Traceable Author Statement more info
located_in tertiary granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: integrin alpha-M

Names: CD11 antigen-like family member B; CR-3 alpha chain; antigen CD11b (p170); cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; integrin, alpha M (complement component 3 receptor 3 subunit); leukocyte adhesion receptor MO1; macrophage antigen alpha polypeptide; macrophage-1 antigen alpha subunit; neutrophil adherence receptor alpha-M subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011719.1 RefSeqGene

Range

5009..77911

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1333

mRNA and Protein(s)

NM_000632.4 → NP_000623.2 integrin alpha-M isoform 2 precursor

See identical proteins and their annotated locations for NP_000623.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal amino acid, compared to isoform 1.

Source sequence(s)

AA436312, AC093520, AK057856, BC096348

Consensus CDS

CCDS45470.1

UniProtKB/Swiss-Prot

P11215, Q4VAK0, Q4VAK1, Q4VAK2

Related

ENSP00000441691.3, ENST00000544665.9

Conserved Domains (4) summary

smart00191
Location:516 → 562

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1129 → 1143

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:614 → 978

Integrin_alpha2; Integrin alpha
NM_001145808.2 → NP_001139280.1 integrin alpha-M isoform 1 precursor

See identical proteins and their annotated locations for NP_001139280.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC093520, BC096348, BM194233, J03925

Consensus CDS

CCDS54004.1

UniProtKB/Swiss-Prot

P11215

Related

ENSP00000496959.1, ENST00000648685.1

Conserved Domains (4) summary

smart00191
Location:517 → 563

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1130 → 1144

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:615 → 979

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

31259975..31332877

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017023216.2 → XP_016878705.1 integrin alpha-M isoform X2
XM_011545851.3 → XP_011544153.1 integrin alpha-M isoform X3

Conserved Domains (2) summary

smart00191
Location:517 → 563

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
XM_006721045.1 → XP_006721108.1 integrin alpha-M isoform X4

Conserved Domains (2) summary

smart00191
Location:516 → 562

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:149 → 324

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
XM_011545850.3 → XP_011544152.1 integrin alpha-M isoform X1

Conserved Domains (4) summary

smart00191
Location:455 → 501

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:87 → 262

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1068 → 1082

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:553 → 917

Integrin_alpha2; Integrin alpha