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prickle2b prickle homolog 2b [ Danio rerio (zebrafish) ]

Gene ID: 368250, updated on 27-Mar-2024

Summary

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Official Symbol
prickle2bprovided by ZNC
Official Full Name
prickle homolog 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030724-6
See related
Ensembl:ENSDARG00000037593 AllianceGenome:ZFIN:ZDB-GENE-030724-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pk2; cb886; prickle2; im:7138215
Summary
Predicted to enable zinc ion binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; melanosome transport; and neural retina development. Is expressed in several structures, including anterior neural keel; immature eye; mesoderm; nervous system; and neural tube. Orthologous to human PRICKLE2 (prickle planar cell polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (19370716..19469079)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (19109037..19306737)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene solute carrier family 2 member 9, like 1 Neighboring gene proteasome 26S subunit, non-ATPase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Veeman MT, et al. Curr Biol, 2003 Apr 15. PMID 12699626
  2. Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms. Mei X, et al. Dev Biol, 2014 Aug 15. PMID 24938409, Free PMC Article
  3. Mutations in prickle orthologs cause seizures in flies, mice, and humans. Tao H, et al. Am J Hum Genet, 2011 Feb 11. PMID 21276947, Free PMC Article
  4. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Bassuk AG, et al. Am J Hum Genet, 2008 Nov. PMID 18976727, Free PMC Article
  5. Functional and evolutionary insights from the Ciona notochord transcriptome. Reeves WM, et al. Development, 2017 Sep 15. PMID 28928284, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish pk2 modulates convergence and extension movements in gastrulation, and retinal neurogenesis.
    Title: Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Kupffer's vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within melanosome transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neural retina development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
prickle-like protein 2; prickle-like protein 2b
Names
prickle homolog 2
prickle-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183343.1 → NP_899186.1  prickle-like protein 2b

    See identical proteins and their annotated locations for NP_899186.1

    Status: PROVISIONAL

    Source sequence(s)
    AY278987
    UniProtKB/TrEMBL
    Q7ZZC4
    Related
    ENSDARP00000135945.1, ENSDART00000162081.2
    Conserved Domains (4) summary
    cd09415
    Location:126 → 184
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:189 → 244
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:249 → 307
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:22 → 118
    PET_Prickle; The PET domain of Prickle

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    19370716..19469079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155827.3 → XP_005155884.1  prickle-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005155884.1

    UniProtKB/TrEMBL
    A0A8M2B1U8, F1REQ6
    Related
    ENSDARP00000146432.1, ENSDART00000186154.1
    Conserved Domains (4) summary
    cd09415
    Location:126 → 184
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:189 → 244
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:249 → 307
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:22 → 118
    PET_Prickle; The PET domain of Prickle
Nucleotide Protein Strain
Heading Accession and Version

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