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prickle1a prickle homolog 1a [ Danio rerio (zebrafish) ]

Gene ID: 368249, updated on 27-Mar-2024

Summary

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Official Symbol
prickle1aprovided by ZNC
Official Full Name
prickle homolog 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030724-5
See related
Ensembl:ENSDARG00000040649 AllianceGenome:ZFIN:ZDB-GENE-030724-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pk1; fk71b09; prickle1; wu:fk71b09
Summary
Predicted to enable zinc ion binding activity. Acts upstream of or within several processes, including animal organ development; gastrulation; and generation of neurons. Is expressed in several structures, including central nervous system; ectoderm; eye; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 25
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (316905..348874, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (294122..325899, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438376 Neighboring gene periphilin-1-like Neighboring gene DNA-binding protein RFX7-like Neighboring gene sizzled Neighboring gene protogenin homolog b (Gallus gallus)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis. Mei X, et al. Dis Model Mech, 2013 May. PMID 23324328, Free PMC Article
  2. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Veeman MT, et al. Curr Biol, 2003 Apr 15. PMID 12699626
  3. Identification and characterization of novel rare mutations in the planar cell polarity gene PRICKLE1 in human neural tube defects. Bosoi CM, et al. Hum Mutat, 2011 Dec. PMID 21901791, Free PMC Article
  4. Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. Mapp OM, et al. Dev Dyn, 2010 Jun. PMID 20503357, Free PMC Article
  5. Tes regulates neural crest migration and axial elongation in Xenopus. Dingwell KS, et al. Dev Biol, 2006 May 1. PMID 16554046

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. uncovered roles for pk1a and pk1b in the epithelial-to-mesenchymal transition (EMT) of pre-migratory NCCs that precedes their collective migration to the periphery.
    Title: Prickle1 is required for EMT and migration of zebrafish cranial neural crest.
  2. Similar to vangl2, loss of zebrafish prickle1a decreases fibronectin protein levels in gastrula embryos.
    Title: Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation.
  3. the wild-type Pk1a partially suppresses the gene knockdown retinal defects but not the mutant forms.
    Title: Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis.
  4. Mechanistically, mir206 targets prickle1a (pk1a) mRNA and as a result regulates c-Jun N-terminal protein kinase 2 (JNK2) phosphorylation.
    Title: MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating c-Jun N-terminal kinase 2 phosphorylation.
  5. homeodomain gene previously shown to be involved in biliary development and in kidney cyst formation
    Title: Disruption of planar cell polarity activity leads to developmental biliary defects.
  6. Wnt11 and Prickle1a are expressed in the dorsal forerunner cells and regulate Kupffer's vesicle morphogenesis.
    Title: Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Kupffer's vesicle development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within Kupffer's vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell migration in hindbrain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell migration involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of digestive tract left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of liver left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart looping IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intrahepatic bile duct development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within intrahepatic bile duct development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural retina development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
prickle homolog 1a; prickle-like protein 1a
Names
pk1a
prickle-like 1 a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183342.2 → NP_899185.2  prickle-like protein 1a

    See identical proteins and their annotated locations for NP_899185.2

    Status: PROVISIONAL

    Source sequence(s)
    AY286492
    UniProtKB/TrEMBL
    Q6WGK5
    Related
    ENSDARP00000059513.5, ENSDART00000059514.7
    Conserved Domains (4) summary
    cd09415
    Location:132 → 191
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:196 → 251
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:256 → 314
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:28 → 124
    PET_Prickle; The PET domain of Prickle

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    316905..348874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005174210.4 → XP_005174267.1  prickle homolog 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BLU1, F1Q6J9
    Conserved Domains (4) summary
    cd09415
    Location:132 → 191
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:196 → 251
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:256 → 314
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:28 → 124
    PET_Prickle; The PET domain of Prickle
Nucleotide Protein Strain
Heading Accession and Version

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