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egr2a early growth response 2a [ Danio rerio (zebrafish) ]

Gene ID: 368241, updated on 27-Mar-2024

Summary

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Official Symbol
egr2aprovided by ZNC
Official Full Name
early growth response 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030723-6
See related
Ensembl:ENSDARG00000044098 AllianceGenome:ZFIN:ZDB-GENE-030723-6
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
frb35
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in hindbrain and hindbrain neural keel. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 17
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (43663486..43677754, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (43672955..43675628, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 365 Neighboring gene 2-aminoethanethiol (cysteamine) dioxygenase b Neighboring gene nuclear receptor binding factor 2a Neighboring gene jumonji domain containing 1Ca

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish. Sun Z, et al. Mech Dev, 2002 Jun. PMID 12175499
  2. Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation. Voltes A, et al. Development, 2019 Jul 22. PMID 31273051
  3. Peripheral axons of the adult zebrafish maxillary barbel extensively remyelinate during sensory appendage regeneration. Moore AC, et al. J Comp Neurol, 2012 Dec 15. PMID 22592645, Free PMC Article
  4. Effects of acetochlor on neurogenesis and behaviour in zebrafish at early developmental stages. Wang H, et al. Chemosphere, 2019 Apr. PMID 33395817
  5. Zinc finger protein 365 is a new maternal LPS-binding protein that defends zebrafish embryos against gram-negative bacterial infections. Du X, et al. FASEB J, 2018 Feb. PMID 29042450

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish gene frb35 encodes a novel zinc finger protein that shares a high homology with Krx-20; the expression domains of frb35 overlap those of krx-20
    Title: A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 SUMO-protein ligase EGR2a; early growth response 2a
Names
krox-20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328404.2 → NP_001315333.1  E3 SUMO-protein ligase EGR2a isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BX927349
    UniProtKB/TrEMBL
    A0A8M1P4S0, E7F266
    Related
    ENSDARP00000072456.5, ENSDART00000077990.6
    Conserved Domains (4) summary
    COG5048
    Location:321 → 382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:295 → 317
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:293 → 317
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:337 → 362
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001359896.1 → NP_001346825.1  E3 SUMO-protein ligase EGR2a isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX927349
    UniProtKB/TrEMBL
    A0A8M9PE40
    Conserved Domains (4) summary
    COG5048
    Location:319 → 380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:291 → 315
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:89 → 154
    DUF3446; Domain of unknown function (DUF3446)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    43663486..43677754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467119.1 → XP_021322794.1  early growth response 2a isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:319 → 380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:291 → 315
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:89 → 154
    DUF3446; Domain of unknown function (DUF3446)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183341.1: Suppressed sequence

    Description
    NM_183341.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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