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Btk Bruton tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 367901, updated on 11-Apr-2024

Summary

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Official Symbol
Btkprovided by RGD
Official Full Name
Bruton tyrosine kinaseprovided by RGD
Primary source
RGD:1359683
See related
Ensembl:ENSRNOG00000052407 AllianceGenome:RGD:1359683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein tyrosine kinase activity. Involved in several processes, including cellular response to molecule of fungal origin; histamine secretion by mast cell; and positive regulation of hypersensitivity. Located in perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human BTK (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 217.2), Thymus (RPKM 46.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102016070..102055448, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97722796..97762315, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105360922..105390580, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA aspartic acid (anticodon AUC) 1 Neighboring gene translocase of inner mitochondrial membrane 8A1 Neighboring gene ribosomal protein L36A Neighboring gene galactosidase, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats. Patel NM, et al. Ann Surg, 2023 Mar 1. PMID 35129479, Free PMC Article
  2. Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Roschewski M, et al. Sci Immunol, 2020 Jun 5. PMID 32503877, Free PMC Article
  3. Nonclinical Safety Assessment of Zanubrutinib: A Novel Irreversible BTK Inhibitor. Zhang C, et al. Int J Toxicol, 2020 May/Jun. PMID 32484067
  4. BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining. Bi KW, et al. Front Oncol, 2020. PMID 32351880, Free PMC Article
  5. Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. Angst D, et al. J Med Chem, 2020 May 28. PMID 32083858

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats.
    Title: Inhibition of Bruton's Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats.
  2. Btk together with PI3-kinase are part of TLR2 multiprotein complex and mediate LTA-induced TLR2 responses in macrophages.
    Title: Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell affinity maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to interleukin-7 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to molecule of fungal origin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eosinophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of B cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of leukocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-17A production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synoviocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type I hypersensitivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type III hypersensitivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteoglycan catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to organic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase BTK
Names
Bruton agammaglobulinemia tyrosine kinase
NP_001007799.2
XP_038955880.1
XP_038955881.1
XP_038955882.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007798.2 → NP_001007799.2  tyrosine-protein kinase BTK

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A0G2K6M9, Q5S255
    Related
    ENSRNOP00000073875.2, ENSRNOT00000086863.2
    Conserved Domains (4) summary
    cd05113
    Location:399 → 654
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:276 → 380
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:219 → 273
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:6 → 168
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    102016070..102055448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099954.2 → XP_038955882.1  tyrosine-protein kinase BTK isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6M9, Q5S255
    Conserved Domains (4) summary
    cd05113
    Location:399 → 654
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:276 → 380
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:219 → 273
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:6 → 168
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

  2. XM_039099952.2 → XP_038955880.1  tyrosine-protein kinase BTK isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6M9, Q5S255
    Conserved Domains (4) summary
    cd05113
    Location:399 → 654
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:276 → 380
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:219 → 273
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:6 → 168
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

  3. XM_039099953.2 → XP_038955881.1  tyrosine-protein kinase BTK isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6M9, Q5S255
    Conserved Domains (4) summary
    cd05113
    Location:399 → 654
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:276 → 380
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:219 → 273
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    cd01238
    Location:6 → 168
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version

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