Bmx BMX non-receptor tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmxprovided by RGD
Official Full Name: BMX non-receptor tyrosine kinaseprovided by RGD
Primary source: RGD:1565643
See related: Ensembl:ENSRNOG00000003705 AllianceGenome:RGD:1565643
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565643
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and peptidyl-tyrosine autophosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Orthologous to human BMX (BMX non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 13.7), Heart (RPKM 9.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (33859128..33921876)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (30227251..30290015)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (31976231..32046326)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effects of dietary K(+) on Bmx were more pronounced
Title: Sodium and potassium regulate endothelial phospholipase C-γ and Bmx.
Location and level of Etk expression in neurons are associated with varied severity of traumatic brain injury
Title: Location and level of Etk expression in neurons are associated with varied severity of traumatic brain injury.
data suggest that Etk/Bmx is activated after neuronal injury; suppressing Etk activity protects against neurodegeneration in ischemic brain
Title: Suppression of Etk/Bmx protects against ischemic brain injury.

Submit: New GeneRIF Correction

General gene information

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Markers

px-24c3 (e-PCR)
- UniSTS:257449

Bmx (e-PCR), detects polymorphism
- UniSTS:265214

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoplasmic tyrosine-protein kinase BMX

NP_001102486.1

EC 2.7.10.1

XP_038955871.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109016.1 → NP_001102486.1 cytoplasmic tyrosine-protein kinase BMX

See identical proteins and their annotated locations for NP_001102486.1

Status: PROVISIONAL

Source sequence(s)

CH474014

UniProtKB/TrEMBL

A6K2L5, F1LVI0

Related

ENSRNOP00000005181.8, ENSRNOT00000005181.8

Conserved Domains (5) summary

cd10399
Location:269 → 374

SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx

cd01238
Location:25 → 151

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

pfam00169
Location:27 → 115

PH; PH domain

pfam07714
Location:397 → 646

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:392 → 647

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

33859128..33921876

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099943.2 → XP_038955871.1 cytoplasmic tyrosine-protein kinase BMX isoform X1

Conserved Domains (3) summary

cd10399
Location:265 → 370

SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx

cd01238
Location:21 → 147

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

cl21453
Location:388 → 643

PKc_like; Protein Kinases, catalytic domain