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Gpr35 G protein-coupled receptor 35 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367315, updated on 13-Apr-2024

Summary

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Official Symbol
Gpr35provided by RGD
Official Full Name
G protein-coupled receptor 35provided by RGD
Primary source
RGD:1309404
See related
Ensembl:ENSRNOG00000062887 AllianceGenome:RGD:1309404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable C-X-C chemokine receptor activity. Involved in negative regulation of neuronal action potential. Located in plasma membrane. Orthologous to human GPR35 (G protein-coupled receptor 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 9.6), Thymus (RPKM 4.6) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr35 in Genome Data Viewer
Location:
9q36
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (100974580..100995330)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (93527165..93539573)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100129428..100141269)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene calpain 10 Neighboring gene U6 spliceosomal RNA Neighboring gene aquaporin 12A Neighboring gene kinesin family member 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional G-protein-coupled receptor 35 is expressed by neurons in the CA1 field of the hippocampus. Alkondon M, et al. Biochem Pharmacol, 2015 Feb 15. PMID 25542997
  2. GPR35 is a functional receptor in rat dorsal root ganglion neurons. Ohshiro H, et al. Biochem Biophys Res Commun, 2008 Jan 11. PMID 17996730
  3. Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. Taniguchi Y, et al. FEBS Lett, 2006 Sep 18. PMID 16934253
  4. Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons. Guo J, et al. J Pharmacol Exp Ther, 2008 Jan. PMID 17940199
  5. Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling. Ronkainen VP, et al. Cardiovasc Res, 2014 Jan 1. PMID 24095869

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR35-mediated kynurenic acid sensing contributes to maintenance of gut microbiota homeostasis in ulcerative colitis.
    Title: GPR35-mediated kynurenic acid sensing contributes to maintenance of gut microbiota homeostasis in ulcerative colitis.
  2. Functional GPR35 receptors were found to be expressed in CA1 field of hippocampus neurons.
    Title: Functional G-protein-coupled receptor 35 is expressed by neurons in the CA1 field of the hippocampus.
  3. screening assays used to identification of small MW agonists; some compounds are species-specific agonists; agonists/ligands include zaprinast, cromolyn & dicumarol
    Title: Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.
  4. We propose that GPR35 modulates nociception and that continued study of this receptor will provide additional insight into the role of kynurenic acid in pain perception.
    Title: GPR35 is a functional receptor in rat dorsal root ganglion neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables C-X-C chemokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in chemokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuronal action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037359.2 → NP_001032436.2  G-protein coupled receptor 35

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6JQX2, G3V962
    Related
    ENSRNOP00000081235.1, ENSRNOT00000114850.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    100974580..100995330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245540.5 → XP_006245602.1  G-protein coupled receptor 35 isoform X1

    See identical proteins and their annotated locations for XP_006245602.1

    UniProtKB/TrEMBL
    A6JQX2, G3V962, Q33BM1
    Conserved Domains (2) summary
    cd14964
    Location:51 → 76
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:39 → 285
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_039084003.2 → XP_038939931.1  G-protein coupled receptor 35 isoform X1

    UniProtKB/TrEMBL
    A6JQX2, G3V962, Q33BM1
    Related
    ENSRNOP00000083273.1
    Conserved Domains (2) summary
    cd14964
    Location:51 → 76
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:39 → 285
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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