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Traip TRAF-interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 367167, updated on 5-Mar-2024

Summary

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Official Symbol
Traipprovided by RGD
Official Full Name
TRAF-interacting proteinprovided by RGD
Primary source
RGD:1309761
See related
Ensembl:ENSRNOG00000030101 AllianceGenome:RGD:1309761
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of interferon-beta production; negative regulation of tumor necrosis factor-mediated signaling pathway; and replication fork processing. Predicted to act upstream of or within negative regulation of NF-kappaB transcription factor activity and signal transduction. Predicted to be located in nucleolus; nucleoplasm; and site of DNA damage. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 31.1), Spleen (RPKM 16.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q32
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117520476..117540253)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108641860..108661640)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116730170..116750528)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene actin-like 11 Neighboring gene CaM kinase-like vesicle-associated Neighboring gene ubiquitin-like modifier activating enzyme 7 Neighboring gene inka box actin regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task. Logue SF, et al. Behav Neurosci, 1997 Feb. PMID 9109628
  2. The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells. Zhou Q, et al. Oncogene, 2009 Mar 12. PMID 19151749, Free PMC Article
  3. TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. Zhang M, et al. J Exp Med, 2012 Sep 24. PMID 22945920, Free PMC Article
  4. TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. Lee SY, et al. J Exp Med, 1997 Apr 7. PMID 9104814, Free PMC Article
  5. TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase. Besse A, et al. Biochem Biophys Res Commun, 2007 Aug 3. PMID 17544371

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRAIP
NP_001102474.1
XP_038937815.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109004.2 → NP_001102474.1  E3 ubiquitin-protein ligase TRAIP

    See identical proteins and their annotated locations for NP_001102474.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162006
    UniProtKB/TrEMBL
    A0A8I6GLQ9, B1WC52, F7ETT8
    Related
    ENSRNOP00000048198.3, ENSRNOT00000052289.5
    Conserved Domains (2) summary
    pfam13639
    Location:7 → 50
    zf-RING_2; Ring finger domain
    cl12013
    Location:106 → 264
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    117520476..117540253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081887.2 → XP_038937815.1  E3 ubiquitin-protein ligase TRAIP isoform X1

    Conserved Domains (1) summary
    COG1196
    Location:4 → 137
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version

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