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Tcf20 transcription factor 20 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366964, updated on 3-Apr-2024

Summary

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Official Symbol
Tcf20provided by RGD
Official Full Name
transcription factor 20provided by RGD
Primary source
RGD:1594486
See related
Ensembl:ENSRNOG00000009585 AllianceGenome:RGD:1594486
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AR1; SPBP
Summary
Predicted to enable DNA-binding transcription factor activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human TCF20 (transcription factor 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 240.6), Spleen (RPKM 179.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115833523..116009790, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113953449..114104166, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123670135..123767797, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 3 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 2 Neighboring gene uncharacterized LOC134479801 Neighboring gene NFAT activating protein with ITAM motif 1 Neighboring gene uncharacterized LOC103692952

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators. Rekdal C, et al. J Biol Chem, 2000 Dec 22. PMID 10995766
  2. Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers. Lyngsø C, et al. J Biol Chem, 2000 Aug 25. PMID 10849425
  3. Molecular characterization of a novel transcription factor that controls stromelysin expression. Sanz L, et al. Mol Cell Biol, 1995 Jun. PMID 7760812, Free PMC Article
  4. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, et al. Mamm Genome, 2000 Sep. PMID 10967130
  5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription factor 20
Names
stromelysin-1 platelet-derived growth factor-responsive element binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130574.1 → NP_001124046.1  transcription factor 20

    See identical proteins and their annotated locations for NP_001124046.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A0A8I5ZW43, A6HT77, D3ZG21
    Related
    ENSRNOP00000012699.4, ENSRNOT00000012699.5
    Conserved Domains (1) summary
    cd15699
    Location:1737 → 1964
    ePHD_TCF20; Extended PHD finger (ePHD) found in transcription factor 20 (TCF-20)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115833523..116009790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765772.4 → XP_008763994.1  transcription factor 20 isoform X3

    See identical proteins and their annotated locations for XP_008763994.1

    UniProtKB/TrEMBL
    A0A8I5ZW43, A6HT77, D3ZG21
    Conserved Domains (1) summary
    cd15699
    Location:1737 → 1964
    ePHD_TCF20; Extended PHD finger (ePHD) found in transcription factor 20 (TCF-20)

  2. XM_063264058.1 → XP_063120128.1  transcription factor 20 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBI4

  3. XM_039079693.2 → XP_038935621.1  transcription factor 20 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBI4, A0A8I5ZW43
    Conserved Domains (1) summary
    cd15699
    Location:1737 → 1964
    ePHD_TCF20; Extended PHD finger (ePHD) found in transcription factor 20 (TCF-20)

  4. XM_063264059.1 → XP_063120129.1  transcription factor 20 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBI4

  5. XM_006242112.5 → XP_006242174.1  transcription factor 20 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZW43
    Conserved Domains (1) summary
    cd15699
    Location:1737 → 1964
    ePHD_TCF20; Extended PHD finger (ePHD) found in transcription factor 20 (TCF-20)

  6. XM_006242110.5 → XP_006242172.1  transcription factor 20 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBI4, A0A8I5ZW43
    Related
    ENSRNOP00000076866.1
    Conserved Domains (1) summary
    cd15699
    Location:1737 → 1964
    ePHD_TCF20; Extended PHD finger (ePHD) found in transcription factor 20 (TCF-20)
Nucleotide Protein Strain
Heading Accession and Version

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