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Rdh5 retinol dehydrogenase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366791, updated on 13-Apr-2024

Summary

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Official Symbol
Rdh5provided by RGD
Official Full Name
retinol dehydrogenase 5provided by RGD
Primary source
RGD:1308849
See related
Ensembl:ENSRNOG00000007784 AllianceGenome:RGD:1308849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rdh1
Summary
Predicted to enable NAD-retinol dehydrogenase activity; protein homodimerization activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in retinoid metabolic process and steroid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in fundus albipunctatus and night blindness. Orthologous to human RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 61.3), Liver (RPKM 61.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1912120..1931836, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1341172..1346863, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3335681..3342573, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene growth differentiation factor 11 Neighboring gene Cd63 molecule Neighboring gene uncharacterized LOC120093529 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus. Lidén M, et al. J Biol Chem, 2001 Dec 28. PMID 11675386
  2. The N-terminus of retinol dehydrogenase type 1 signals cytosolic orientation in the microsomal membrane. Wang J, et al. Biochemistry, 2001 Oct 23. PMID 11601977
  3. Gene structure, expression analysis, and membrane topology of RDH4. Romert A, et al. Exp Cell Res, 2000 Apr 10. PMID 10739682
  4. 11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus. Gonzalez-Fernandez F, et al. Mol Vis, 1999 Dec 30. PMID 10617778
  5. Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue. Wang J, et al. Biochem J, 1999 Feb 15. PMID 9931293, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in retinoid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of BLOC-1 complex IEA
Inferred from Electronic Annotation
more info
  
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
retinol dehydrogenase 5
Names
11-cis retinol dehydrogenase
9-cis-retinol dehydrogenase
retinol dehydrogenase 1 (11-cis)
retinol dehydrogenase 5 (11-cis/9-cis)
retinol dehydrogenase type 5
NP_001385693.1
NP_001385694.1
NP_001385695.1
XP_063120086.1
XP_063120087.1
XP_063120088.1
XP_063120089.1
XP_063120090.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398764.1 → NP_001385693.1  retinol dehydrogenase 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K1R4
    Related
    ENSRNOP00000071951.1, ENSRNOT00000081756.2
    Conserved Domains (1) summary
    cl21454
    Location:31 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001398765.1 → NP_001385694.1  retinol dehydrogenase 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K1R4
    Conserved Domains (1) summary
    cl21454
    Location:31 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_001398766.1 → NP_001385695.1  retinol dehydrogenase 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K1R4
    Conserved Domains (1) summary
    cl21454
    Location:31 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1912120..1931836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264019.1 → XP_063120089.1  retinol dehydrogenase 5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K1R4

  2. XM_063264018.1 → XP_063120088.1  retinol dehydrogenase 5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K1R4

  3. XM_063264017.1 → XP_063120087.1  retinol dehydrogenase 5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K1R4

  4. XM_063264016.1 → XP_063120086.1  retinol dehydrogenase 5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K1R4

  5. XM_063264020.1 → XP_063120090.1  retinol dehydrogenase 5 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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