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Ptch2 patched 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366452, updated on 11-Apr-2024

Summary

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Official Symbol
Ptch2provided by RGD
Official Full Name
patched 2provided by RGD
Primary source
RGD:1309039
See related
Ensembl:ENSRNOG00000057616 AllianceGenome:RGD:1309039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Predicted to be involved in regulation of cell growth and smoothened signaling pathway. Predicted to act upstream of or within several processes, including epidermal cell fate specification; hair cycle; and positive regulation of epidermal cell differentiation. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH2 (patched 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 27.7), Testes (RPKM 10.5) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptch2 in Genome Data Viewer
Location:
5q36
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135808856..135829087)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130571956..130592506)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135962252..135983816)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S12-like Neighboring gene eukaryotic translation initiation factor 2B subunit gamma Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene BTB domain containing 19 Neighboring gene dynein light chain Tctex-type 4 Neighboring gene polo-like kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model. Zhang YD, et al. Exp Mol Med, 2017 Dec 15. PMID 29244790, Free PMC Article
  2. A missense mutation in PTCH2 underlies dominantly inherited NBCCS in a Chinese family. Fan Z, et al. J Med Genet, 2008 May. PMID 18285427
  3. Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. Nieuwenhuis E, et al. Mol Cell Biol, 2006 Sep. PMID 16914743, Free PMC Article
  4. Characterization of two patched receptors for the vertebrate hedgehog protein family. Carpenter D, et al. Proc Natl Acad Sci U S A, 1998 Nov 10. PMID 9811851, Free PMC Article
  5. Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. Adolphe C, et al. J Invest Dermatol, 2014 Jul. PMID 24492243

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of the Hh signaling pathway by silencing PTC1 and PTC2 may reduce inflammation and may ultimately promote spinal cord injury recovery
    Title: Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hedgehog family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables hedgehog receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables smoothened binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell fate determination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epidermal cell fate specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epidermis development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hair cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of epidermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skin development ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein patched homolog 2
Names
patched homolog 1
patched homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108975.2 → NP_001102445.2  protein patched homolog 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    M0RA51
    Related
    ENSRNOP00000069388.2, ENSRNOT00000087353.2
    Conserved Domains (1) summary
    cl25655
    Location:12 → 1142
    Patched; Patched family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    135808856..135829087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110467.2 → XP_038966395.1  protein patched homolog 2 isoform X4

    Conserved Domains (1) summary
    cl25655
    Location:12 → 731
    Patched; Patched family

  2. XM_039110463.2 → XP_038966391.1  protein patched homolog 2 isoform X1

    Conserved Domains (1) summary
    cl25655
    Location:12 → 1041
    Patched; Patched family

  3. XM_063288115.1 → XP_063144185.1  protein patched homolog 2 isoform X2

  4. XM_039110466.2 → XP_038966394.1  protein patched homolog 2 isoform X2

    UniProtKB/TrEMBL
    A6JZB8
    Conserved Domains (1) summary
    cl25655
    Location:1 → 1029
    Patched; Patched family

  5. XM_017593539.3 → XP_017449028.1  protein patched homolog 2 isoform X3

    UniProtKB/TrEMBL
    A6JZB8

RNA

  1. XR_010066445.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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