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Polr1A RNA polymerase I subunit A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36617, updated on 4-Apr-2024

Summary

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Official Symbol
Polr1Aprovided by FlyBase
Official Full Name
RNA polymerase I subunit Aprovided by FlyBase
Primary source
FLYBASE:FBgn0019938
Locus tag
Dmel_CG10122
See related
AllianceGenome:FB:FBgn0019938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
153129_at; CG10122; Dmel\CG10122; DmRPA1; RPA1; RPA190; RpI1; Rpl1
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Predicted to be part of RNA polymerase I complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Polr1A in Genome Data Viewer
Location:
51B4-51B6; 2-72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14595611..14601216, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10483116..10488721, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tout-velu Neighboring gene uncharacterized protein Neighboring gene Lamin C Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : PsiU5-44 Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 1 Neighboring gene transformer 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the gene coding for the largest subunit of RNA polymerase I (A) of Drosophila melanogaster. Knackmuss S, et al. Mol Gen Genet, 1997 Feb 20. PMID 9065685
  2. Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity. Martínez Corrales G, et al. Cell Rep, 2020 Feb 11. PMID 32049000, Free PMC Article
  3. Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I. Seither P, et al. Mol Gen Genet, 1997 Jun. PMID 9236775
  4. Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Shaffer CD, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12376620, Free PMC Article
  5. The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. Delanoue R, et al. Dev Cell, 2010 Jun 15. PMID 20627082

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase I activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase I ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RNA polymerase I subunit A
Names
CG10122-PA
Polr1A-PA
RNA polymerase I
RNA polymerase I subunit
NP_523743.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14595611..14601216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079019.3 → NP_523743.1  RNA polymerase I subunit A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523743.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91875, Q8MRE2, Q9V732
    Related
    FBpp0086640
    Conserved Domains (5) summary
    cd02735
    Location:1166 → 1638
    RNAP_I_Rpa1_C; Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain
    cd01435
    Location:18 → 982
    RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain
    TIGR02390
    Location:14 → 1009
    RNA_pol_rpoA1; DNA-directed RNA polymerase subunit A'
    pfam04998
    Location:936 → 1593
    RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5
    cl00082
    Location:1057 → 1119
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91875.2 P91875

Gene LinkOut

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