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Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 365865, updated on 11-Apr-2024

Summary

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Official Symbol
Pip5k1aprovided by RGD
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase, type 1, alphaprovided by RGD
Primary source
RGD:1306127
See related
Ensembl:ENSRNOG00000021068 AllianceGenome:RGD:1306127
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pip5k1b
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Predicted to act upstream of or within fibroblast migration and phosphatidylinositol biosynthetic process. Predicted to be located in several cellular components, including lamellipodium; nuclear speck; and ruffle membrane. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 124.7), Muscle (RPKM 98.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pip5k1a in Genome Data Viewer
Location:
2q34
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185317319..185361859, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182628299..182671584, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196227669..196270949, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 4 Neighboring gene uncharacterized LOC134485649 Neighboring gene vacuolar protein sorting 72 homolog Neighboring gene tropomodulin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation. Chao WT, et al. J Cell Biol, 2010 Jul 26. PMID 20660631, Free PMC Article
  2. Phosphatidylinositol-4-phosphate 5-kinase type 1α attenuates Aβ production by promoting non-amyloidogenic processing of amyloid precursor protein. Wu PF, et al. FASEB J, 2020 Sep. PMID 32686865
  3. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. Luo B, et al. Cell Signal, 2004 Aug. PMID 15157668
  4. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. Ishihara H, et al. J Biol Chem, 1996 Sep 27. PMID 8798574
  5. The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. Kisseleva M, et al. Mol Cell Biol, 2005 May. PMID 15870270, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein.
    Title: Phosphatidylinositol-4-phosphate 5-kinase type 1α attenuates Aβ production by promoting non-amyloidogenic processing of amyloid precursor protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in fibroblast migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IEA
Inferred from Electronic Annotation
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
Names
68 kDa type I phosphatidylinositol 4-phosphate 5-kinase
PIP5K1-alpha
PIP5KIalpha
phosphatidylinositol 4-phosphate 5-kinase type I alpha
phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
ptdIns(4)P-5-kinase 1 alpha
NP_001036086.2
XP_008759537.1
XP_008759538.1
XP_038958707.1
XP_038958708.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042621.2 → NP_001036086.2  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    D3ZSI8
    UniProtKB/TrEMBL
    A0A8I6ANU4
    Related
    ENSRNOP00000097963.1, ENSRNOT00000117151.1
    Conserved Domains (1) summary
    cd17306
    Location:64 → 439
    PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185317319..185361859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761316.2 → XP_008759538.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

    See identical proteins and their annotated locations for XP_008759538.1

    UniProtKB/TrEMBL
    A0A8I6A5T8, A0A8I6ANU4, A6K2U4
    Related
    ENSRNOP00000086696.1
    Conserved Domains (1) summary
    smart00330
    Location:94 → 434
    PIPKc; Phosphatidylinositol phosphate kinases

  2. XM_008761315.2 → XP_008759537.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3

    UniProtKB/TrEMBL
    A0A8I6ANU4
    Conserved Domains (1) summary
    smart00330
    Location:95 → 435
    PIPKc; Phosphatidylinositol phosphate kinases

  3. XM_039102780.2 → XP_038958708.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2

    UniProtKB/TrEMBL
    A0A8I6ANU4, A0A8L2QH45
    Related
    ENSRNOP00000028609.5
    Conserved Domains (1) summary
    cd17306
    Location:78 → 453
    PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins

  4. XM_039102779.2 → XP_038958707.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1

    UniProtKB/TrEMBL
    A0A8I6ANU4
    Conserved Domains (1) summary
    cd17306
    Location:79 → 454
    PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZSI8.1 GenPept UniProtKB/Swiss-Prot:D3ZSI8

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