U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Paip1 poly(A) binding protein interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365684, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Paip1provided by RGD
Official Full Name
poly(A) binding protein interacting protein 1provided by RGD
Primary source
RGD:1305668
See related
Ensembl:ENSRNOG00000058580 AllianceGenome:RGD:1305668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable translation activator activity. Predicted to be involved in positive regulation of translation. Orthologous to human PAIP1 (poly(A) binding protein interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 243.2), Kidney (RPKM 213.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2q15
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (53255916..53282965)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (51523190..51550241)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (52300921..52328212)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene small nucleolar RNA SNORD36 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene similar to human chromosome 5 open reading frame 34 Neighboring gene transmembrane protein 267

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Craig AW, et al. Nature, 1998 Apr 2. PMID 9548260
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect viral translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of mCRD-mediated mRNA stability complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
polyadenylate-binding protein-interacting protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108937.2 → NP_001102407.1  polyadenylate-binding protein-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_001102407.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6I5V5, B2RZ22
    Conserved Domains (1) summary
    pfam02854
    Location:48 → 264
    MIF4G; MIF4G domain

  2. NM_001399758.1 → NP_001386687.1  polyadenylate-binding protein-interacting protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  3. NM_001399759.1 → NP_001386688.1  polyadenylate-binding protein-interacting protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6I5V5
    Related
    ENSRNOP00000069142.2, ENSRNOT00000081157.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    53255916..53282965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760778.4 → XP_008759000.1  polyadenylate-binding protein-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JVP5
    Related
    ENSRNOP00000069568.2
    Conserved Domains (2) summary
    PHA03160
    Location:36 → 116
    PHA03160; hypothetical protein; Provisional
    pfam02854
    Location:161 → 377
    MIF4G; MIF4G domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous