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CG16935 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36540, updated on 26-Apr-2024

Summary

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Official Symbol
CG16935provided by FlyBase
Primary source
FLYBASE:FBgn0033883
Locus tag
Dmel_CG16935
See related
AllianceGenome:FB:FBgn0033883
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG16935; DM_7303260
Summary
Predicted to enable trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in dystonia. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
50C6-50C6; 2-68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13860349..13862002, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9747854..9749507, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44367 Neighboring gene uncharacterized protein Neighboring gene tumbleweed Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-like activating enzyme 3 Neighboring gene short stop Neighboring gene DJ-1alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TEMPLE: analysing population genetic variation at transcription factor binding sites. Litovchenko M, et al. Mol Ecol Resour, 2016 Nov. PMID 27106869
  2. Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. Axelsson E, et al. BMC Bioinformatics, 2011 Aug 17. PMID 21849035, Free PMC Article
  3. Selection, recombination and demographic history in Drosophila miranda. Bachtrog D, et al. Genetics, 2006 Dec. PMID 17028331, Free PMC Article
  4. The Stearoyl-CoA Desaturase-1 (Desat1) in Drosophila cooperated with Myc to Induce Autophagy and Growth, a Potential New Link to Tumor Survival. Paiardi C, et al. Genes (Basel), 2017 Apr 28. PMID 28452935, Free PMC Article
  5. High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy. Belozerov VE, et al. Mol Cell Biol, 2012 Sep. PMID 22801366, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG16935-PA
CG16935-PB
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
trans-2-enoyl-CoA reductase, mitochondrial
NP_001286396.1
NP_610914.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13860349..13862002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137070.2 → NP_610914.2  uncharacterized protein Dmel_CG16935, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610914.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V6U9
    UniProtKB/TrEMBL
    H8F4T6, Q58CJ2
    Related
    FBpp0086748
    Conserved Domains (2) summary
    cd08290
    Location:23 → 355
    ETR; 2-enoyl thioester reductase (ETR)
    COG0604
    Location:23 → 349
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

  2. NM_001299467.1 → NP_001286396.1  uncharacterized protein Dmel_CG16935, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286396.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V6U9
    UniProtKB/TrEMBL
    H8F4T6, Q58CJ2
    Conserved Domains (2) summary
    cd08290
    Location:23 → 355
    ETR; 2-enoyl thioester reductase (ETR)
    COG0604
    Location:23 → 349
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H8F4T6 H8F4T6
Q9V6U9.2 Q9V6U9

Gene LinkOut

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