U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ssh3 slingshot protein phosphatase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365396, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ssh3provided by RGD
Official Full Name
slingshot protein phosphatase 3provided by RGD
Primary source
RGD:1308679
See related
Ensembl:ENSRNOG00000018878 AllianceGenome:RGD:1308679
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm. Orthologous to human SSH3 (slingshot protein phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 110.7), Kidney (RPKM 89.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q43
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210986604..210994975, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201557167..201565577, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219511908..219519398, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAD9 checkpoint clamp component A Neighboring gene DNA polymerase delta 4, accessory subunit Neighboring gene uncharacterized LOC103691274 Neighboring gene ankyrin repeat domain 13D Neighboring gene G protein-coupled receptor kinase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein phosphatase Slingshot homolog 3
Names
SSH-3L
SSH-like protein 3
slingshot homolog 3
NP_001012217.1
XP_038941428.1
XP_038941431.1
XP_038941444.1
XP_038941454.1
XP_038941487.1
XP_063125903.1
XP_063125906.1
XP_063125910.1
XP_063125914.1
XP_063125917.1
XP_063125918.1
XP_063125925.1
XP_063125928.1
XP_063125929.1
XP_063125931.1
XP_063125932.1
XP_063125934.1
XP_063125939.1
XP_063125941.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012217.1 → NP_001012217.1  protein phosphatase Slingshot homolog 3

    See identical proteins and their annotated locations for NP_001012217.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083600
    UniProtKB/Swiss-Prot
    Q5XIS1
    Conserved Domains (3) summary
    cd11652
    Location:3 → 256
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:326 → 461
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:269 → 317
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210986604..210994975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269844.1 → XP_063125914.1  protein phosphatase Slingshot homolog 3 isoform X7

  2. XM_063269833.1 → XP_063125903.1  protein phosphatase Slingshot homolog 3 isoform X3

  3. XM_039085503.2 → XP_038941431.1  protein phosphatase Slingshot homolog 3 isoform X2

    Conserved Domains (3) summary
    cd11652
    Location:32 → 279
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14571
    Location:350 → 493
    DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
    pfam08766
    Location:296 → 347
    DEK_C; DEK C terminal domain

  4. XM_039085500.2 → XP_038941428.1  protein phosphatase Slingshot homolog 3 isoform X1

    Conserved Domains (3) summary
    cd11652
    Location:32 → 279
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14571
    Location:352 → 495
    DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
    pfam08766
    Location:298 → 349
    DEK_C; DEK C terminal domain

  5. XM_063269847.1 → XP_063125917.1  protein phosphatase Slingshot homolog 3 isoform X9

  6. XM_063269861.1 → XP_063125931.1  protein phosphatase Slingshot homolog 3 isoform X14

  7. XM_063269859.1 → XP_063125929.1  protein phosphatase Slingshot homolog 3 isoform X13

  8. XM_063269855.1 → XP_063125925.1  protein phosphatase Slingshot homolog 3 isoform X11

  9. XM_063269840.1 → XP_063125910.1  protein phosphatase Slingshot homolog 3 isoform X5

  10. XM_063269862.1 → XP_063125932.1  protein phosphatase Slingshot homolog 3 isoform X14

  11. XM_063269858.1 → XP_063125928.1  protein phosphatase Slingshot homolog 3 isoform X12

  12. XM_063269848.1 → XP_063125918.1  protein phosphatase Slingshot homolog 3 isoform X10

  13. XM_039085526.2 → XP_038941454.1  protein phosphatase Slingshot homolog 3 isoform X8

    UniProtKB/TrEMBL
    A6HYW8
    Conserved Domains (3) summary
    cd11652
    Location:3 → 257
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14571
    Location:324 → 467
    DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
    pfam08766
    Location:270 → 321
    DEK_C; DEK C terminal domain

  14. XM_039085516.2 → XP_038941444.1  protein phosphatase Slingshot homolog 3 isoform X6

    UniProtKB/TrEMBL
    F1LR78
    Related
    ENSRNOP00000025546.7
    Conserved Domains (3) summary
    cd11652
    Location:3 → 257
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14571
    Location:328 → 471
    DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
    pfam08766
    Location:274 → 325
    DEK_C; DEK C terminal domain

  15. XM_063269836.1 → XP_063125906.1  protein phosphatase Slingshot homolog 3 isoform X4

  16. XM_063269864.1 → XP_063125934.1  protein phosphatase Slingshot homolog 3 isoform X15

  17. XM_063269871.1 → XP_063125941.1  protein phosphatase Slingshot homolog 3 isoform X16

  18. XM_063269869.1 → XP_063125939.1  protein phosphatase Slingshot homolog 3 isoform X16

  19. XM_039085559.2 → XP_038941487.1  protein phosphatase Slingshot homolog 3 isoform X17

    Conserved Domains (3) summary
    cd11652
    Location:32 → 279
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    pfam08766
    Location:298 → 349
    DEK_C; DEK C terminal domain
    cl28904
    Location:352 → 435
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIS1.1 GenPept UniProtKB/Swiss-Prot:Q5XIS1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous