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Echs1 Enoyl-CoA hydratase, short chain 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36536, updated on 4-Apr-2024

Summary

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Official Symbol
Echs1provided by FlyBase
Official Full Name
Enoyl-CoA hydratase, short chain 1provided by FlyBase
Primary source
FLYBASE:FBgn0033879
Locus tag
Dmel_CG6543
See related
AllianceGenome:FB:FBgn0033879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18645; CG6543; Dmel\CG6543
Summary
Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval muscle system; germline cell; and gut section. Orthologous to human ECHS1 (enoyl-CoA hydratase, short chain 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
50C6-50C6; 2-68 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13852947..13854331, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9740452..9741836, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-9379 stem loop Neighboring gene antisense RNA:CR44367 Neighboring gene uncharacterized protein Neighboring gene tumbleweed

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Terhzaz S, et al. J Biol Chem, 2006 Jul 7. PMID 16670086
  2. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Von Ohlen T, et al. Infect Immun, 2012 Oct. PMID 22851751, Free PMC Article
  3. Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study. Cuesta-Astroz Y, et al. Front Genet, 2021. PMID 34394179, Free PMC Article
  4. Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Palanker L, et al. Cell Metab, 2009 Mar. PMID 19254568, Free PMC Article
  5. Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila. Hoffmann J, et al. Aging (Albany NY), 2013 Apr. PMID 23765091, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3-hydroxypropionyl-CoA dehydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enoyl-CoA hydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Enoyl-CoA hydratase, short chain 1
Names
CG6543-PA
CG6543-PB
Echs1-PA
Echs1-PB
NP_610910.1
NP_725332.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13852947..13854331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137066.4 → NP_610910.1  Enoyl-CoA hydratase, short chain 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610910.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JR58
    Related
    FBpp0086769
    Conserved Domains (1) summary
    cl23717
    Location:37 → 294
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  2. NM_166014.3 → NP_725332.1  Enoyl-CoA hydratase, short chain 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725332.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JR58
    Related
    FBpp0086770
    Conserved Domains (1) summary
    cl23717
    Location:37 → 294
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JR58 Q7JR58

Gene LinkOut

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