Nkd1 NKD inhibitor of WNT signaling pathway 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nkd1provided by RGD
Official Full Name: NKD inhibitor of WNT signaling pathway 1provided by RGD
Primary source: RGD:1308491
See related: Ensembl:ENSRNOG00000014293 AllianceGenome:RGD:1308491
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable PDZ domain binding activity. Predicted to be involved in negative regulation of convergent extension involved in axis elongation; positive regulation of protein catabolic process; and regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm. Orthologous to human NKD1 (NKD inhibitor of WNT signaling pathway 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 262.0), Adrenal (RPKM 129.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (34649803..34722846, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (18476344..18549380, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (19434720..19509087, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128487 (e-PCR)
- UniSTS:211795

Nkd1 (e-PCR), detects polymorphism
- UniSTS:471175

AU025097 (e-PCR)
- UniSTS:115600

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axis elongation	ISO Inferred from Sequence Orthology more info
involved_in convergent extension	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein naked cuticle homolog 1

Names: NKD1, WNT signaling pathway inhibitor; naked cuticle 1 homolog; naked cuticle homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271381.1 → NP_001258310.1 protein naked cuticle homolog 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

D4AAV5

Related

ENSRNOP00000019301.7, ENSRNOT00000019301.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

34649803..34722846 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108894.1: Suppressed sequence

Description

NM_001108894.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from mouse, laboratory: Nkd1 (GeneID:93960).