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cbc crowded by cid [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36494, updated on 4-Jan-2025

Summary

Official Symbol
cbcprovided by FlyBase
Official Full Name
crowded by cidprovided by FlyBase
Primary source
FLYBASE:FBgn0033842
Locus tag
Dmel_CG5970
See related
AllianceGenome:FB:FBgn0033842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cbc; CBC; cg5970; CG5970; Dmel\CG5970
Summary
Predicted to enable ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity and ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be part of tRNA-intron endonuclease complex. Predicted to be active in nucleus. Is expressed in organism. Used to study pontocerebellar hypoplasia type 10. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 10. Orthologous to human CLP1 (cleavage factor polyribonucleotide kinase subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See cbc in Genome Data Viewer
Location:
50A11-50A11; 2-68 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13483512..13485391, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9371017..9372896, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Golgin 97 Neighboring gene arrow Neighboring gene uncharacterized protein Neighboring gene centromere identifier Neighboring gene bb in a boxcar

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of mRNA cleavage factor complex  
is_active_in nucleus  
part_of tRNA-intron endonuclease complex  

General protein information

Preferred Names
crowded by cid
Names
CG5970-PA
cbc-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13483512..13485391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137032.4 → NP_610876.1  crowded by cid [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610876.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K284
    Related
    FBpp0086820
    Conserved Domains (4) summary
    COG5623
    Location:11 → 412
    CLP1; Predicted GTPase subunit of the pre-mRNA cleavage complex [Translation, ribosomal structure and biogenesis]
    pfam06807
    Location:309 → 420
    Clp1; Pre-mRNA cleavage complex II protein Clp1
    pfam16573
    Location:9 → 102
    CLP1_N; N-terminal beta-sandwich domain of polyadenylation factor
    pfam16575
    Location:116 → 301
    CLP1_P; mRNA cleavage and polyadenylation factor CLP1 P-loop
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