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Blk BLK proto-oncogene, Src family tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 364403, updated on 11-Apr-2024

Summary

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Official Symbol
Blkprovided by RGD
Official Full Name
BLK proto-oncogene, Src family tyrosine kinaseprovided by RGD
Primary source
RGD:1308859
See related
Ensembl:ENSRNOG00000010798 AllianceGenome:RGD:1308859
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of leukocyte proliferation; and regulation of leukocyte apoptotic process. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 11 and systemic lupus erythematosus. Orthologous to human BLK (BLK proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 119.7), Thymus (RPKM 28.5) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
15p12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41802701..41841004, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (37626746..37665053, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46555552..46593778, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene GATA binding protein 4 Neighboring gene uncharacterized LOC102548615 Neighboring gene uncharacterized LOC120097012 Neighboring gene uncharacterized LOC120097013 Neighboring gene family with sequence similarity 167, member A Neighboring gene L-threonine dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Borowiec M, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19667185, Free PMC Article
  2. The effect of cardiac ischemic preconditioning on rat left ventricular gene expression profile. Canatan H. Cell Biochem Funct, 2008 Mar-Apr. PMID 17562528
  3. [Restoration of the function of bilateral hand grip at the expense of the fingers of the same hand]. Azolov VV. Ortop Travmatol Protez, 1977 Apr. PMID 876631
  4. Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population. Ito I, et al. Arthritis Rheum, 2009 Feb. PMID 19180478
  5. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Liu H, et al. Nature, 2018 Nov. PMID 30356214

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112647

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Blk
Names
B lymphoid tyrosine kinase
NP_001020922.1
XP_006252250.1
XP_038949478.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025751.1 → NP_001020922.1  tyrosine-protein kinase Blk

    See identical proteins and their annotated locations for NP_001020922.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098683
    UniProtKB/TrEMBL
    F7EWL4, Q4KM97
    Related
    ENSRNOP00000015021.4, ENSRNOT00000015021.7
    Conserved Domains (4) summary
    pfam07714
    Location:235 → 484
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:114 → 213
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:56 → 109
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:227 → 490
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    41802701..41841004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252188.4 → XP_006252250.1  tyrosine-protein kinase Blk isoform X1

    Conserved Domains (4) summary
    pfam07714
    Location:290 → 539
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:169 → 268
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:111 → 164
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:282 → 545
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039093550.2 → XP_038949478.1  tyrosine-protein kinase Blk isoform X2

    Conserved Domains (2) summary
    cl15255
    Location:1 → 78
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:92 → 355
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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