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Sin3A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36382, updated on 10-May-2024

Summary

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Official Symbol
Sin3Aprovided by FlyBase
Primary source
FLYBASE:FBgn0022764
Locus tag
Dmel_CG8815
See related
AllianceGenome:FB:FBgn0022764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
159A11T; 27/3; 97/15; CG8815; Dmel\CG8815; dSin3; dSin3A; ES2-3; ESTS:159A11T; EY2-9; l(2)08269; l(2)k02703; l(2)k05415; l(2)k09715; ld; Sin 3A; sin3; Sin3; SIN3; sin3a; sin3A; Sin3a; SIN3A; sni3
Summary
Enables chromatin binding activity and protein heterodimerization activity. Involved in several processes, including determination of adult lifespan; larval somatic muscle development; and regulation of transcription, DNA-templated. Located in chromatin; nucleus; and polytene chromosome. Part of Sin3-type complex and transcription repressor complex. Is expressed in organism. Used to study cancer. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A) and SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
49B5-49B7; 2-67 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12575240..12592917, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8462745..8480422, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 301a1 Neighboring gene Adenylate kinase 6 Neighboring gene stand still Neighboring gene Chloride channel-b Neighboring gene long non-coding RNA:CR30055 Neighboring gene long non-coding RNA:CR45279 Neighboring gene long non-coding RNA:CR43909 Neighboring gene Amphiphysin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inter-isoform-dependent Regulation of the Drosophila Master Transcriptional Regulator SIN3. Chaubal A, et al. J Biol Chem, 2016 May 27. PMID 27129248, Free PMC Article
  2. Sin3: insight into its transcription regulatory functions. Kadamb R, et al. Eur J Cell Biol, 2013 Aug-Sep. PMID 24189169
  3. Drosophila SIN3 is required at multiple stages of development. Sharma V, et al. Dev Dyn, 2008 Oct. PMID 18816856
  4. A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription. Liu M, et al. J Biol Chem, 2020 Jan 10. PMID 31776190, Free PMC Article
  5. A positive role of Sin3A in regulating Notch signaling during Drosophila wing development. Zhang X, et al. Cell Signal, 2019 Jan. PMID 30316814

See all (181) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription.
    Title: A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription.
  2. Sin3A promotes Notch transcription. Notch autoregulates its own transcription and this is mediated by Sin3A.
    Title: A positive role of Sin3A in regulating Notch signaling during Drosophila wing development.
  3. findings suggest that while individual SIN3 complex components work through distinct molecular mechanisms, they each make a substantial contribution to the overall function of this highly conserved histone deacetylase complex
    Title: Systematic Analysis of SIN3 Histone Modifying Complex Components During Development.
  4. Ttk69 causes the histone deacetylation-mediated repression of tll via the interaction of Pits and Sin3A
    Title: Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation.
  5. study reveals that SIN3 is an important epigenetic regulator directly connecting methionine metabolism and histone modification.
    Title: The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism.
  6. Sin3A as a key buffer controlling muscle responsiveness to transcription factors in the formation of muscle identity.
    Title: Whole-genome analysis of muscle founder cells implicates the chromatin regulator Sin3A in muscle identity.
  7. Adult flies with knockdown Sin3A had reduced climbing ability and were more sensitive to oxidative stress. Sin3A knockdown flies had decreased longevity compared to wild type, but no changes in expression of many well-categorized aging genes were observed
    Title: SIN3 is critical for stress resistance and modulates adult lifespan.
  8. data suggest that Sin3A influences a specific step of tumorigenesis by regulating a module of genes involved in cell invasion
    Title: Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors.
  9. Sin3A plays a wide variety of roles in a developing tissue such as the wing disc and that its function is not limited to regulating the cell cycle.
    Title: Identification of genetic suppressors of the Sin3A knockdown wing phenotype.
  10. SIN3 isoforms serve distinct roles in transcriptional regulation by partnering with different histone-modifying enzymes
    Title: Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval somatic muscle development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in larval somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Sin3-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sin3A
Names
CG8815-PA
CG8815-PB
CG8815-PC
CG8815-PD
CG8815-PE
CG8815-PF
CG8815-PG
CG8815-PH
CG8815-PI
CG8815-PJ
Sin3A-PA
Sin3A-PB
Sin3A-PC
Sin3A-PD
Sin3A-PE
Sin3A-PF
Sin3A-PG
Sin3A-PH
Sin3A-PI
Sin3A-PJ
enhancer of GMR-sina 2-3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12575240..12592917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165916.3 → NP_725188.1  Sin3A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725188.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77025, Q5U0Y0
    Related
    FBpp0087000
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1498 → 1706
    Sin3a_C; C-terminal domain of Sin3a protein

  2. NM_001201984.2 → NP_001188913.1  Sin3A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188913.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z927, O17142
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1498 → 1706
    Sin3a_C; C-terminal domain of Sin3a protein

  3. NM_165915.3 → NP_725187.1  Sin3A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725187.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77025, Q5U0Y0
    Related
    FBpp0087003
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1498 → 1706
    Sin3a_C; C-terminal domain of Sin3a protein

  4. NM_136955.4 → NP_610799.2  Sin3A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610799.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z927, O17142
    Related
    FBpp0087001
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1498 → 1706
    Sin3a_C; C-terminal domain of Sin3a protein

  5. NM_001299426.1 → NP_001286355.1  Sin3A, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286355.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF93, O17143
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1498 → 1706
    Sin3a_C; C-terminal domain of Sin3a protein

  6. NM_001316418.1 → NP_001303347.1  Sin3A, isoform J [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUN9, O17143
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1498 → 1706
    Sin3a_C; C-terminal domain of Sin3a protein

  7. NM_165917.4 → NP_725189.1  Sin3A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725189.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z928, O17143
    Related
    FBpp0087002
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1498 → 1706
    Sin3a_C; C-terminal domain of Sin3a protein

  8. NM_001299425.1 → NP_001286354.1  Sin3A, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF82, O77025
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1713
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1133
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1496 → 1704
    Sin3a_C; C-terminal domain of Sin3a protein

  9. NM_001201983.2 → NP_001188912.1  Sin3A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188912.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77025, Q5U0Y0
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1715
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1129
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1498 → 1706
    Sin3a_C; C-terminal domain of Sin3a protein

  10. NM_001259353.2 → NP_001246282.1  Sin3A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246282.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K765, O77025
    Conserved Domains (4) summary
    COG5602
    Location:238 → 1719
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:291 → 335
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:1034 → 1133
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:1502 → 1710
    Sin3a_C; C-terminal domain of Sin3a protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K765 A0A0B4K765
A0A0B4LF82 A0A0B4LF82
A0A0B4LF93 A0A0B4LF93
A0A126GUN9 A0A126GUN9
A1Z927 A1Z927
A1Z928 A1Z928
O17142 O17142
O17143 O17143
O77025 O77025
Q5U0Y0 Q5U0Y0
Q960C3 Q960C3

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