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Grap GRB2-related adaptor protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 363616, updated on 29-Feb-2024

Summary

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Official Symbol
Grapprovided by RGD
Official Full Name
GRB2-related adaptor proteinprovided by RGD
Primary source
RGD:1306884
See related
Ensembl:ENSRNOG00000002599 AllianceGenome:RGD:1306884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in sensory perception of sound. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114. Orthologous to several human genes including GRAP (GRB2 related adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 317.9), Spleen (RPKM 150.9) and 4 other tissues See more
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Genomic context

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Location:
10q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46798423..46851524)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (46298965..46352057)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47930633..47949774)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene B9 domain containing 1 Neighboring gene epsin 2 Neighboring gene transfer RNA valine (anticodon AAC) 10 Neighboring gene uncharacterized LOC134480802 Neighboring gene solute carrier family 5 member 10 Neighboring gene family with sequence similarity 83, member G Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss. Li C, et al. Proc Natl Acad Sci U S A, 2019 Jan 22. PMID 30610177, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112733

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GRB2-related adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025749.1 → NP_001020920.1  GRB2-related adapter protein

    See identical proteins and their annotated locations for NP_001020920.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098740
    UniProtKB/TrEMBL
    Q4KM68
    Related
    ENSRNOP00000003515.3, ENSRNOT00000003515.5
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11948
    Location:2 → 55
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl17036
    Location:162 → 214
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    46798423..46851524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269509.1 → XP_063125579.1  GRB2-related adapter protein isoform X1

  2. XM_039086467.2 → XP_038942395.1  GRB2-related adapter protein isoform X2

    UniProtKB/TrEMBL
    Q4KM68
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11948
    Location:2 → 55
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl17036
    Location:162 → 214
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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