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Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363509, updated on 13-Apr-2024

Summary

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Official Symbol
Arhgef6provided by RGD
Official Full Name
Rac/Cdc42 guanine nucleotide exchange factor 6provided by RGD
Primary source
RGD:1359674
See related
Ensembl:ENSRNOG00000000869 AllianceGenome:RGD:1359674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to be located in cell-cell junction and lamellipodium. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 46. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 165.0), Spleen (RPKM 150.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq36
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (140182734..140302812, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (135145447..135264636, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (159722031..159841344, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 15 Neighboring gene CD40 ligand Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene RNA binding motif protein, X-linked Neighboring gene transmembrane 9 superfamily member 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biochemical and functional characterisation of αPIX, a specific regulator of axonal and dendritic branching in hippocampal neurons. Totaro A, et al. Biol Cell, 2012 Sep. PMID 22554054
  2. Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. Kutsche K, et al. Nat Genet, 2000 Oct. PMID 11017088
  3. betaPIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells. Momboisse F, et al. J Cell Sci, 2009 Mar 15. PMID 19261846
  4. c-Cbl regulates αPix-mediated cell migration and invasion. Seong MW, et al. Biochem Biophys Res Commun, 2014 Dec 12. PMID 25450678
  5. Affixin activates Rac1 via betaPIX in C2C12 myoblast. Matsuda C, et al. FEBS Lett, 2008 Apr 9. PMID 18325335

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. c-Cbl negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl in C6 and A172 glioma cells is responsible for their malignant behavior
    Title: c-Cbl regulates αPix-mediated cell migration and invasion.
  2. alphaPIX and GIT2 are required for neuronal differentiation.
    Title: Biochemical and functional characterisation of αPIX, a specific regulator of axonal and dendritic branching in hippocampal neurons.
  3. betaPix is identified as the guanine nucleotide-exchange factor integrating Rac1 activation to PLD1 and the exocytotic process.
    Title: betaPIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 6
Names
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005565.2 → NP_001005565.2  rho guanine nucleotide exchange factor 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    Related
    ENSRNOP00000001158.7, ENSRNOT00000001158.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    140182734..140302812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099908.2 → XP_038955836.1  rho guanine nucleotide exchange factor 6 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GGI3
    Conserved Domains (7) summary
    cd12060
    Location:186 → 242
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:266 → 443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:474 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:596 → 625
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:626 → 712
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:139 → 184
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:25 → 141
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

  2. XM_008773653.4 → XP_008771875.1  rho guanine nucleotide exchange factor 6 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GGI3
    Related
    ENSRNOP00000088717.1
    Conserved Domains (8) summary
    cd12060
    Location:186 → 242
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:29 → 129
    CH; Calponin homology domain
    cd00160
    Location:266 → 443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:474 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:491 → 572
    PH; PH domain
    pfam16523
    Location:652 → 738
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:596 → 649
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:139 → 184
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  3. XM_008773652.4 → XP_008771874.1  rho guanine nucleotide exchange factor 6 isoform X4

    UniProtKB/TrEMBL
    D3ZWQ8
    Conserved Domains (8) summary
    cd12060
    Location:186 → 242
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:29 → 129
    CH; Calponin homology domain
    cd00160
    Location:266 → 443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:474 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:491 → 572
    PH; PH domain
    pfam16523
    Location:659 → 745
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:593 → 656
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:139 → 184
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  4. XM_039099907.2 → XP_038955835.1  rho guanine nucleotide exchange factor 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZX43
    Conserved Domains (7) summary
    cd12060
    Location:186 → 242
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:266 → 443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:474 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:598 → 667
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:668 → 754
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:139 → 184
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:25 → 141
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

  5. XM_008773651.4 → XP_008771873.1  rho guanine nucleotide exchange factor 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZX43
    Related
    ENSRNOP00000084113.1
    Conserved Domains (8) summary
    cd12060
    Location:186 → 242
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:29 → 129
    CH; Calponin homology domain
    cd00160
    Location:266 → 443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:474 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:491 → 572
    PH; PH domain
    pfam16523
    Location:694 → 780
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:598 → 691
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:139 → 184
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  6. XM_039099906.2 → XP_038955834.1  rho guanine nucleotide exchange factor 6 isoform X2

    UniProtKB/TrEMBL
    D3ZWQ8
    Conserved Domains (7) summary
    cd12060
    Location:186 → 242
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:266 → 443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:474 → 572
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:598 → 674
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:675 → 761
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:139 → 184
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21265
    Location:25 → 141
    CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

  7. XM_063280154.1 → XP_063136224.1  rho guanine nucleotide exchange factor 6 isoform X8

  8. XM_017602114.3 → XP_017457603.1  rho guanine nucleotide exchange factor 6 isoform X7

    UniProtKB/Swiss-Prot
    Q5XXR3
    Conserved Domains (5) summary
    cd12060
    Location:8 → 64
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:88 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:296 → 394
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:420 → 520
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:523 → 609
    betaPIX_CC; betaPIX coiled coil

  9. XM_063280155.1 → XP_063136225.1  rho guanine nucleotide exchange factor 6 isoform X9

  10. XM_039099910.2 → XP_038955838.1  rho guanine nucleotide exchange factor 6 isoform X7

    UniProtKB/Swiss-Prot
    Q5XXR3
    Conserved Domains (5) summary
    cd12060
    Location:8 → 64
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:88 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:296 → 394
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:420 → 520
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:523 → 609
    betaPIX_CC; betaPIX coiled coil

  11. XM_008773654.4 → XP_008771876.1  rho guanine nucleotide exchange factor 6 isoform X7

    UniProtKB/Swiss-Prot
    Q5XXR3
    Conserved Domains (5) summary
    cd12060
    Location:8 → 64
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:88 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:296 → 394
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:420 → 520
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:523 → 609
    betaPIX_CC; betaPIX coiled coil

  12. XM_039099909.2 → XP_038955837.1  rho guanine nucleotide exchange factor 6 isoform X7

    UniProtKB/Swiss-Prot
    Q5XXR3
    Conserved Domains (5) summary
    cd12060
    Location:8 → 64
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:88 → 265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:296 → 394
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:420 → 520
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:523 → 609
    betaPIX_CC; betaPIX coiled coil

  13. XM_063280158.1 → XP_063136228.1  rho guanine nucleotide exchange factor 6 isoform X13

    UniProtKB/TrEMBL
    A0A8I6G8W1

  14. XM_063280157.1 → XP_063136227.1  rho guanine nucleotide exchange factor 6 isoform X12

    UniProtKB/TrEMBL
    A0A8I6APF5

  15. XM_063280156.1 → XP_063136226.1  rho guanine nucleotide exchange factor 6 isoform X11

  16. XM_039099911.1 → XP_038955839.1  rho guanine nucleotide exchange factor 6 isoform X10

    Related
    ENSRNOP00000096317.1, ENSRNOT00000096866.1
    Conserved Domains (4) summary
    cd00160
    Location:5 → 179
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:210 → 308
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:334 → 434
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:437 → 523
    betaPIX_CC; betaPIX coiled coil
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XXR3.1 GenPept UniProtKB/Swiss-Prot:Q5XXR3

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