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Hdac8 histone deacetylase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363481, updated on 11-Apr-2024

Summary

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Symbol
Hdac8provided by RGD
Full Name
histone deacetylase 8provided by RGD
Primary source
RGD:1562895
See related
Ensembl:ENSRNOG00000003122 AllianceGenome:RGD:1562895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HD8; RGD1562895
Summary
Enables chromatin binding activity and deacetylase activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of macromolecule metabolic process; and negative regulation of osteoblast differentiation. Located in nucleus. Biomarker of amphetamine abuse; hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 26.7), Brain (RPKM 23.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (71425240..71632865, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (67385288..67593014, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (72163777..72370058, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099193 Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Neighboring gene phosphorylase kinase regulatory subunit alpha 1 Neighboring gene ribosomal protein S27a, pseudogene 3 Neighboring gene kelch domain containing 2 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of Class I and Class II a/b Histone Deacetylase is Dysregulated in Hypertensive Animal Models. Kee HJ, et al. Korean Circ J, 2017 May. PMID 28567090, Free PMC Article
  2. Transcription regulation mechanism of the syntaxin 1A gene via protein kinase A. Nakayama T, et al. Biochem J, 2017 Jul 11. PMID 28559304
  3. Roles of HDAC2 and HDAC8 in Cardiac Remodeling in Renovascular Hypertensive Rats and the Effects of Valproic Acid Sodium. Li RF, et al. Pharmacology, 2017. PMID 27673327
  4. Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders. Wedel T, et al. Neurogastroenterol Motil, 2006 Jul. PMID 16771768
  5. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. Ito K, et al. N Engl J Med, 2005 May 12. PMID 15888697

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that HDAC4 and HDAC8 may serve as key upstream mediators of MAPK in regulating the IL1betainduced cartilage catabolic and degradation.
    Title: Histone deacetylase-4 and histone deacetylase-8 regulate interleukin-1β-induced cartilage catabolic degradation through MAPK/JNK and ERK pathways.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone decrotonylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone decrotonylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone decrotonylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein lysine deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to forskolin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to trichostatin A IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein modification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in response to 11-deoxycorticosterone IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone deacetylase 8
Names
protein deacetylase HDAC8
protein decrotonylase HDAC8
NP_001119845.2
XP_017457598.1
XP_038955828.1
XP_063136216.1
XP_063136217.1
XP_063136218.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126373.2 → NP_001119845.2  histone deacetylase 8

    See identical proteins and their annotated locations for NP_001119845.2

    Status: VALIDATED

    Source sequence(s)
    BC162023, FM086081
    UniProtKB/Swiss-Prot
    B1WC68
    UniProtKB/TrEMBL
    A0A8I6GB67
    Related
    ENSRNOP00000004224.4, ENSRNOT00000004224.7
    Conserved Domains (1) summary
    cd10000
    Location:16 → 377
    HDAC8; Histone deacetylase 8 (HDAC8)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    71425240..71632865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280147.1 → XP_063136217.1  histone deacetylase 8 isoform X3

  2. XM_017602109.3 → XP_017457598.1  histone deacetylase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZP78

  3. XM_063280146.1 → XP_063136216.1  histone deacetylase 8 isoform X2

  4. XM_039099900.2 → XP_038955828.1  histone deacetylase 8 isoform X4

    UniProtKB/TrEMBL
    A6IQE7
    Conserved Domains (1) summary
    cl17011
    Location:16 → 246
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  5. XM_063280148.1 → XP_063136218.1  histone deacetylase 8 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1WC68.1 GenPept UniProtKB/Swiss-Prot:B1WC68

Gene LinkOut

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