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Ppp2r5d protein phosphatase 2, regulatory subunit B', delta [ Rattus norvegicus (Norway rat) ]

Gene ID: 363193, updated on 13-Apr-2024

Summary

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Symbol
Ppp2r5dprovided by RGD
Full Name
protein phosphatase 2, regulatory subunit B', deltaprovided by RGD
Primary source
RGD:1306666
See related
Ensembl:ENSRNOG00000016849 AllianceGenome:RGD:1306666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphoprotein phosphatase activity and protein phosphatase activator activity. Involved in negative regulation of peptidyl-threonine phosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 35. Orthologous to human PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 151.8), Thymus (RPKM 140.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp2r5d in Genome Data Viewer
Location:
9q12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21767963..21797997)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14270364..14300396)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16580995..16610425)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene canopy FGF signaling regulator 3 Neighboring gene glycine N-methyltransferase Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene kelch domain containing 3 Neighboring gene male-enhanced antigen 1 Neighboring gene ribosomal RNA processing 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573. Ranieri A, et al. J Mol Cell Cardiol, 2018 Feb. PMID 29294329, Free PMC Article
  2. Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Ahn JH, et al. Proc Natl Acad Sci U S A, 2007 Feb 20. PMID 17301223, Free PMC Article
  3. Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Louis JV, et al. Proc Natl Acad Sci U S A, 2011 Apr 26. PMID 21482799, Free PMC Article
  4. A phosphatase cascade by which rewarding stimuli control nucleosomal response. Stipanovich A, et al. Nature, 2008 Jun 12. PMID 18496528, Free PMC Article
  5. Bod1 regulates protein phosphatase 2A at mitotic kinetochores. Porter IM, et al. Nat Commun, 2013. PMID 24157919, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427099.1 → NP_001414028.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    21767963..21797997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267359.1 → XP_063123429.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2

    UniProtKB/TrEMBL
    A0A8I6A6K6

  2. XM_017596731.3 → XP_017452220.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1

    UniProtKB/TrEMBL
    Q499R1
    Conserved Domains (2) summary
    PLN00122
    Location:488 → 588
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:180 → 583
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  3. XM_001062510.8 → XP_001062510.4  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2

    See identical proteins and their annotated locations for XP_001062510.4

    UniProtKB/TrEMBL
    A0A8I6A6K6, Q499R1
    Related
    ENSRNOP00000086619.1
    Conserved Domains (2) summary
    PLN00122
    Location:487 → 587
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:179 → 582
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  4. XM_006244570.5 → XP_006244632.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1

    See identical proteins and their annotated locations for XP_006244632.1

    UniProtKB/TrEMBL
    Q499R1
    Conserved Domains (2) summary
    PLN00122
    Location:488 → 588
    PLN00122; serine/threonine protein phosphatase 2A; Provisional
    pfam01603
    Location:180 → 583
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
Nucleotide Protein Strain
Heading Accession and Version

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