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Sin3a SIN3 transcription regulator family member A [ Rattus norvegicus (Norway rat) ]

Gene ID: 363067, updated on 11-Apr-2024

Summary

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Official Symbol
Sin3aprovided by RGD
Official Full Name
SIN3 transcription regulator family member Aprovided by RGD
Primary source
RGD:1311598
See related
Ensembl:ENSRNOG00000032254 AllianceGenome:RGD:1311598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables RNA binding activity. Involved in several processes, including aging; cellular response to dopamine; and regulation of transcription from RNA polymerase II promoter in response to oxidative stress. Located in chromatin. Part of protein-containing complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 103.8), Adrenal (RPKM 99.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q24
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66377471..66432150)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57481539..57536195)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61748590..61803314)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene snurportin 1 Neighboring gene uncharacterized LOC103693102 Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene uncharacterized LOC102553607 Neighboring gene uncharacterized LOC120094171 Neighboring gene uncharacterized LOC120094172 Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene nei-like DNA glycosylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST. Dharap A, et al. ASN Neuro, 2013 Oct 23. PMID 24063527, Free PMC Article
  2. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. Park JH, et al. J Clin Invest, 2008 Jun. PMID 18464933, Free PMC Article
  3. A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states. Géranton SM, et al. J Neurosci, 2007 Jun 6. PMID 17553988, Free PMC Article
  4. In vivo GSH depletion induces c-myc expression by modulation of chromatin protein complexes. Torres L, et al. Free Radic Biol Med, 2009 Jun 1. PMID 19289167
  5. Epigenetic mechanisms in the dopamine D2 receptor-dependent inhibition of the prolactin gene. Liu JC, et al. Mol Endocrinol, 2005 Jul. PMID 15731170

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MeCP2 is an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex
    Title: MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to dopamine IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to tert-butyl hydroperoxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cerebral cortex neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of hormone levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to methylglyoxal ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organonitrogen compound IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Sin3-type complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
paired amphipathic helix protein Sin3a
Names
SIN3 homolog A, transcription regulator
SIN3 transcription regulator homolog A
transcriptional regulator, SIN3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395640.1 → NP_001382569.1  paired amphipathic helix protein Sin3a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    D3ZBP2
    Conserved Domains (1) summary
    COG5602
    Location:8 → 1214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    66377471..66432150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766301.4 → XP_008764523.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_008764523.1

    UniProtKB/TrEMBL
    D3ZBP2
    Conserved Domains (1) summary
    COG5602
    Location:8 → 1214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

  2. XM_063265753.1 → XP_063121823.1  paired amphipathic helix protein Sin3a isoform X1

  3. XM_039081736.2 → XP_038937664.1  paired amphipathic helix protein Sin3a isoform X1

    UniProtKB/TrEMBL
    D3ZBP2
    Related
    ENSRNOP00000055480.3
    Conserved Domains (1) summary
    COG5602
    Location:8 → 1214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

  4. XM_008766299.4 → XP_008764521.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_008764521.1

    UniProtKB/TrEMBL
    D3ZBP2
    Conserved Domains (1) summary
    COG5602
    Location:8 → 1214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

  5. XM_039081735.2 → XP_038937663.1  paired amphipathic helix protein Sin3a isoform X1

    UniProtKB/TrEMBL
    D3ZBP2
    Conserved Domains (1) summary
    COG5602
    Location:8 → 1214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

  6. XM_008766302.4 → XP_008764524.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_008764524.1

    UniProtKB/TrEMBL
    D3ZBP2
    Conserved Domains (1) summary
    COG5602
    Location:8 → 1214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

  7. XM_063265751.1 → XP_063121821.1  paired amphipathic helix protein Sin3a isoform X1

  8. XM_039081737.2 → XP_038937665.1  paired amphipathic helix protein Sin3a isoform X1

    UniProtKB/TrEMBL
    D3ZBP2
    Conserved Domains (1) summary
    COG5602
    Location:8 → 1214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

  9. XM_039081734.2 → XP_038937662.1  paired amphipathic helix protein Sin3a isoform X1

    UniProtKB/TrEMBL
    D3ZBP2
    Conserved Domains (1) summary
    COG5602
    Location:8 → 1214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

  10. XM_006243129.5 → XP_006243191.1  paired amphipathic helix protein Sin3a isoform X1

    See identical proteins and their annotated locations for XP_006243191.1

    UniProtKB/TrEMBL
    D3ZBP2
    Conserved Domains (1) summary
    COG5602
    Location:8 → 1214
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

  11. XM_063265752.1 → XP_063121822.1  paired amphipathic helix protein Sin3a isoform X1

  12. XM_063265750.1 → XP_063121820.1  paired amphipathic helix protein Sin3a isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108761.1: Suppressed sequence

    Description
    NM_001108761.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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