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Mybpc1 myosin binding protein C1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362867, updated on 13-Apr-2024

Summary

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Official Symbol
Mybpc1provided by RGD
Official Full Name
myosin binding protein C1provided by RGD
Primary source
RGD:735102
See related
Ensembl:ENSRNOG00000056493 AllianceGenome:RGD:735102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable myosin binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within muscle contraction. Predicted to be located in myosin filament. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1B and lethal congenital contracture syndrome 4. Orthologous to human MYBPC1 (myosin binding protein C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 7577.9) See more
Orthologs
human mouse all
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Genomic context

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Location:
7q13
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (24817770..24903681, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22930350..23015981, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (29086159..29171909, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene choline phosphotransferase 1 Neighboring gene synaptonemal complex protein 3 Neighboring gene uncharacterized LOC102554140 Neighboring gene uncharacterized LOC120093549 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 33 Neighboring gene Spi-C transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of pathogenic T cells and autoantibodies in C-protein-induced autoimmune polymyositis. Matsumoto Y, et al. J Neuroimmunol, 2007 Oct. PMID 17900708
  2. Myosin-binding protein C (MyBP-C) in cardiac muscle and contractility. Winegrad S. Adv Exp Med Biol, 2003. PMID 15098652
  3. Peripheral nervous system-specific genes identified by subtractive cDNA cloning. Akopian AN, et al. J Biol Chem, 1995 Sep 8. PMID 7673161
  4. Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle. Luther PK, et al. J Mol Biol, 2008 Dec 5. PMID 18817784, Free PMC Article
  5. Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. Ackermann MA, et al. Mol Biol Cell, 2009 Jun. PMID 19403693, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A new ligand of obscurin at the M-band, MyBP-C slow variant-1 and suggest that their interaction contributes to the assembly of M-and A-bands, is identified.
    Title: Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.
  2. The distribution of MyBP-C in the A-bands of cardiac and skeletal muscles and compare this to the A-band structure in cardiac muscle of MyBP-C-deficient mice, was investigated.
    Title: Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle.
  3. These findings suggest that C-protein-induced EAM is formed by activation of C-protein-specific T cells along with antibodies against conformational epitopes in C-protein but that there are undetermined factors related to the disease progression.
    Title: Characterization of pathogenic T cells and autoantibodies in C-protein-induced autoimmune polymyositis.
  4. Myosin-binding protein C (MyBP-C) has roles in cardiac muscle and contractility [review]
    Title: Myosin-binding protein C (MyBP-C) in cardiac muscle and contractility.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables myosin binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin-binding protein C, slow-type
Names
muscle C-protein
myosin binding protein C, slow type
slow MyBP-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100758.3 → NP_001094228.3  myosin-binding protein C, slow-type

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K7Q0, A0A8I5ZT65
    Related
    ENSRNOP00000074295.2, ENSRNOT00000079235.2
    Conserved Domains (6) summary
    cd00063
    Location:646 → 735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1073 → 1162
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:235 → 268
    THB; Tri-helix bundle domain
    cd00096
    Location:86 → 89
    Ig; Ig strand A [structural motif]
    cd05894
    Location:557 → 642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    cl11960
    Location:85 → 185
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    24817770..24903681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263768.1 → XP_063119838.1  myosin-binding protein C, slow-type isoform X16

    UniProtKB/TrEMBL
    A0A8I5ZTA0

  2. XM_008765256.4 → XP_008763478.1  myosin-binding protein C, slow-type isoform X12

    UniProtKB/TrEMBL
    A0A8I6ATF3
    Related
    ENSRNOP00000069067.2
    Conserved Domains (7) summary
    cd00096
    Location:1051 → 1116
    Ig; Immunoglobulin domain
    cd05894
    Location:518 → 603
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:521 → 603
    IG_like; Immunoglobulin like
    cd00063
    Location:607 → 696
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1034 → 1123
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:51 → 135
    ig; Immunoglobulin domain
    cl11960
    Location:844 → 901
    Ig; Immunoglobulin domain

  3. XM_063263767.1 → XP_063119837.1  myosin-binding protein C, slow-type isoform X14

  4. XM_063263764.1 → XP_063119834.1  myosin-binding protein C, slow-type isoform X7

  5. XM_063263766.1 → XP_063119836.1  myosin-binding protein C, slow-type isoform X10

  6. XM_008765249.4 → XP_008763471.1  myosin-binding protein C, slow-type isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZWN5
    Conserved Domains (7) summary
    cd00096
    Location:1076 → 1141
    Ig; Immunoglobulin domain
    cd05894
    Location:543 → 628
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:546 → 628
    IG_like; Immunoglobulin like
    cd00063
    Location:632 → 721
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1059 → 1148
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:76 → 160
    ig; Immunoglobulin domain
    cl11960
    Location:869 → 926
    Ig; Immunoglobulin domain

  7. XM_008765257.4 → XP_008763479.1  myosin-binding protein C, slow-type isoform X13

    UniProtKB/TrEMBL
    A0A8I6ATF3
    Related
    ENSRNOP00000081596.1
    Conserved Domains (7) summary
    cd00096
    Location:1047 → 1112
    Ig; Immunoglobulin domain
    cd05894
    Location:532 → 617
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:535 → 617
    IG_like; Immunoglobulin like
    cd00063
    Location:621 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1030 → 1119
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:65 → 149
    ig; Immunoglobulin domain
    cl11960
    Location:840 → 897
    Ig; Immunoglobulin domain

  8. XM_008765251.4 → XP_008763473.1  myosin-binding protein C, slow-type isoform X6

    UniProtKB/TrEMBL
    A0A8I6ATF3
    Conserved Domains (7) summary
    cd00096
    Location:1065 → 1130
    Ig; Immunoglobulin domain
    cd05894
    Location:532 → 617
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:535 → 617
    IG_like; Immunoglobulin like
    cd00063
    Location:621 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1048 → 1137
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:65 → 149
    ig; Immunoglobulin domain
    cl11960
    Location:858 → 915
    Ig; Immunoglobulin domain

  9. XM_063263765.1 → XP_063119835.1  myosin-binding protein C, slow-type isoform X9

  10. XM_063263763.1 → XP_063119833.1  myosin-binding protein C, slow-type isoform X2

  11. XM_008765250.4 → XP_008763472.1  myosin-binding protein C, slow-type isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZT65
    Related
    ENSRNOP00000088357.1
    Conserved Domains (7) summary
    cd00096
    Location:1072 → 1137
    Ig; Immunoglobulin domain
    cd05894
    Location:557 → 642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:560 → 642
    IG_like; Immunoglobulin like
    cd00063
    Location:646 → 735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1055 → 1144
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:90 → 174
    ig; Immunoglobulin domain
    cl11960
    Location:865 → 922
    Ig; Immunoglobulin domain

  12. XM_008765246.4 → XP_008763468.1  myosin-binding protein C, slow-type isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZT65
    Conserved Domains (7) summary
    cd00096
    Location:1090 → 1155
    Ig; Immunoglobulin domain
    cd05894
    Location:557 → 642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:560 → 642
    IG_like; Immunoglobulin like
    cd00063
    Location:646 → 735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1073 → 1162
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:90 → 174
    ig; Immunoglobulin domain
    cl11960
    Location:883 → 940
    Ig; Immunoglobulin domain

  13. XM_008765258.4 → XP_008763480.1  myosin-binding protein C, slow-type isoform X15

    UniProtKB/TrEMBL
    A0A8I6AAS2
    Related
    ENSRNOP00000089644.1
    Conserved Domains (8) summary
    cd00096
    Location:1047 → 1112
    Ig; Immunoglobulin domain
    cd05894
    Location:532 → 617
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:535 → 617
    IG_like; Immunoglobulin like
    cd00063
    Location:621 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1030 → 1119
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:65 → 149
    ig; Immunoglobulin domain
    pfam03755
    Location:150 → 249
    YicC_N; YicC-like family, N-terminal region
    cl11960
    Location:840 → 897
    Ig; Immunoglobulin domain

  14. XM_008765255.4 → XP_008763477.1  myosin-binding protein C, slow-type isoform X11

    UniProtKB/TrEMBL
    A0A8I6AAS2
    Conserved Domains (8) summary
    cd00096
    Location:1065 → 1130
    Ig; Immunoglobulin domain
    cd05894
    Location:532 → 617
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:535 → 617
    IG_like; Immunoglobulin like
    cd00063
    Location:621 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1048 → 1137
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:65 → 149
    ig; Immunoglobulin domain
    pfam03755
    Location:150 → 249
    YicC_N; YicC-like family, N-terminal region
    cl11960
    Location:858 → 915
    Ig; Immunoglobulin domain

  15. XM_008765253.4 → XP_008763475.1  myosin-binding protein C, slow-type isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZT65
    Conserved Domains (7) summary
    cd00096
    Location:1072 → 1137
    Ig; Immunoglobulin domain
    cd05894
    Location:557 → 642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:560 → 642
    IG_like; Immunoglobulin like
    cd00063
    Location:646 → 735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1055 → 1144
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:90 → 174
    ig; Immunoglobulin domain
    cl11960
    Location:865 → 922
    Ig; Immunoglobulin domain

  16. XM_008765247.4 → XP_008763469.1  myosin-binding protein C, slow-type isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZT65
    Conserved Domains (7) summary
    cd00096
    Location:1090 → 1155
    Ig; Immunoglobulin domain
    cd05894
    Location:557 → 642
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:560 → 642
    IG_like; Immunoglobulin like
    cd00063
    Location:646 → 735
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1073 → 1162
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:90 → 174
    ig; Immunoglobulin domain
    cl11960
    Location:883 → 940
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63518.1 GenPept UniProtKB/Swiss-Prot:Q63518

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