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Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362837, updated on 5-Mar-2024

Summary

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Official Symbol
Ndufs7provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase core subunit S7provided by RGD
Primary source
RGD:1310013
See related
Ensembl:ENSRNOG00000024568 AllianceGenome:RGD:1310013
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protease binding activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in neuron projection; neuronal cell body; and synaptic membrane. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 1089.7), Heart (RPKM 1047.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10103226..10110862, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9452556..9460135, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12318776..12326403, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 1 Neighboring gene guanidinoacetate N-methyltransferase Neighboring gene transfer RNA asparagine (anticodon GUU) 8 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 3 Neighboring gene PWWP domain containing 3A, DNA repair factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of two novel synaptic γ-secretase associated proteins that affect amyloid β-peptide levels without altering Notch processing. Frykman S, et al. Neurochem Int, 2012 Jul. PMID 22521230
  2. Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Andreazza AC, et al. Arch Gen Psychiatry, 2010 Apr. PMID 20368511
  3. Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene. Leong DW, et al. J Biol Chem, 2012 Jun 8. PMID 22535952, Free PMC Article
  4. Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency. Ugalde C, et al. Hum Mol Genet, 2004 Mar 15. PMID 14749350
  5. Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns. Triepels RH, et al. J Biol Chem, 2001 Mar 23. PMID 11112787

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105684

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to NADH dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in electron transport coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Names
NADH dehydrogenase (ubiquinone) Fe-S protein 7
NADH-ubiquinone oxidoreductase Fe-S protein 7
NP_001008525.1
XP_006241034.1
XP_038935332.1
XP_038935333.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008525.1 → NP_001008525.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

    See identical proteins and their annotated locations for NP_001008525.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086574
    UniProtKB/TrEMBL
    A0A8I6AES7, A0A8I6B2Z5, A6K8N6, Q5RJN0
    Related
    ENSRNOP00000095566.1, ENSRNOT00000099635.1
    Conserved Domains (1) summary
    PRK06411
    Location:68 → 218
    PRK06411; NADH dehydrogenase subunit B; Validated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10103226..10110862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240972.5 → XP_006241034.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006241034.1

    UniProtKB/TrEMBL
    A0A8I6AES7, A0A8I6B2Z5, A6K8N6, Q5RJN0
    Related
    ENSRNOP00000092039.1
    Conserved Domains (1) summary
    PRK06411
    Location:68 → 218
    PRK06411; NADH dehydrogenase subunit B; Validated

  2. XM_039079404.1 → XP_038935332.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6AES7
    Conserved Domains (1) summary
    PRK06411
    Location:76 → 226
    PRK06411; NADH-quinone oxidoreductase subunit NuoB

  3. XM_039079405.2 → XP_038935333.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6K8N7
    Conserved Domains (1) summary
    PRK06411
    Location:1 → 132
    PRK06411; NADH-quinone oxidoreductase subunit NuoB
Nucleotide Protein Strain
Heading Accession and Version

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