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Kpna6 karyopherin subunit alpha 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362607, updated on 3-Apr-2024

Summary

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Official Symbol
Kpna6provided by RGD
Official Full Name
karyopherin subunit alpha 6provided by RGD
Primary source
RGD:1306570
See related
Ensembl:ENSRNOG00000000127 AllianceGenome:RGD:1306570
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule metabolic process; and protein import into nucleus. Predicted to be located in cytoplasm and host cell. Predicted to be active in nucleoplasm. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 288.6), Kidney (RPKM 271.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147272466..147307523, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141988111..142021483, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (147852738..147867600, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351039 Neighboring gene coiled coil domain containing 28B Neighboring gene taxilin alpha Neighboring gene transmembrane protein 39b Neighboring gene KH RNA binding domain containing, signal transduction associated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth. Plant KE, et al. Pharmacogenet Genomics, 2006 Sep. PMID 16906019
  2. H7N9 Influenza A Virus Exhibits Importin-α7-Mediated Replication in the Mammalian Respiratory Tract. Bertram S, et al. Am J Pathol, 2017 Apr. PMID 28189564
  3. Importin α7 is essential for zygotic genome activation and early mouse development. Rother F, et al. PLoS One, 2011 Mar 29. PMID 21479251, Free PMC Article
  4. Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. Sakakida Y, et al. J Biol Chem, 2005 Apr 8. PMID 15689618
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC124892

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within maternal process involved in female pregnancy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within viral genome replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in host cell IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
importin subunit alpha-7
Names
karyopherin (importin) alpha 6
karyopherin (importin) alpha 6-like
karyopherin alpha 6 (importin alpha 7)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015029.2 → NP_001015029.2  importin subunit alpha-7

    See identical proteins and their annotated locations for NP_001015029.2

    Status: PROVISIONAL

    Source sequence(s)
    BC105813
    UniProtKB/TrEMBL
    A0A8I5ZNJ2, Q3KR98
    Related
    ENSRNOP00000079464.1, ENSRNOT00000096749.1
    Conserved Domains (2) summary
    COG5064
    Location:41 → 530
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:259 → 284
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    147272466..147307523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110358.2 → XP_038966286.1  importin subunit alpha-7 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZS1, A0A8I5ZNJ2
    Related
    ENSRNOP00000071158.1
    Conserved Domains (2) summary
    COG5064
    Location:36 → 525
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:254 → 279
    ARM; armadillo repeat [structural motif]

  2. XM_039110360.2 → XP_038966288.1  importin subunit alpha-7 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNJ2, Q56R15
    Conserved Domains (2) summary
    COG5064
    Location:33 → 522
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:251 → 276
    ARM; armadillo repeat [structural motif]

  3. XM_063288025.1 → XP_063144095.1  importin subunit alpha-7 isoform X2

    UniProtKB/TrEMBL
    Q56R15
Nucleotide Protein Strain
Heading Accession and Version

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